Version 2.78

Description

Naloxone is a pure opioid antagonist and, when taken at recommended doses, has no physiological effects in the absence of an opioid agonist. Intravenous naloxone becomes effective within two minutes of injection, but oral or sublingual naloxone has little effect due to its poor absorption. Therefore, intravenous naloxone is used to treat opioid overdose, and it is used as a sublingual combination with buprenorphine, an opioid agonist-antagonist used to treat chronic opioid-dependence, to lower buprenorphine's abuse potential as follows: when the combination is taken sublingually as prescribed, naloxone exerts little effect and buprenorphine's effects predominate; however, if crushed and injected intravenously, naloxone's antagonist properties reverse the agonist effects of buprenorphine and can precipitate withdrawal. PMID: 19368419 Nalaxone levels along with its inactive metabolite, naloxone-3-glucuronide (N3G), may be measured to monitor compliance or identify illicit opioid drug use. Source: Regenstrief LOINC, PMID: 19368419

Basic Part Properties

Part Display Name
Naloxone-3-glucuronide
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-04-27
Construct for LOINC Short Name
Naloxone-3G

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP266980-4

Language Variants Get Info

Tag Language Translation
it-IT Italian (Italy) Naloxone-3-glucuronide
zh-CN Chinese (China) 钠洛酮-3-葡糖苷酸
Synonyms: 纳洛酮-3-葡糖苷酸;那诺松-3-葡糖苷酸
es-ES Spanish (Spain) Naloxona-3-glucurónido