Version 2.77

Description

Rifampicin (RIF) is a first line drug used to treat Mycobacterium tuberculosis (TB). It inhibits transcription by binding with the rpoB encoded beta-subunit of the DNA-dependent RNA polymerase (RNAP). The majority of the mutations across bacterial species occurs in the 81 bp region of cluster, also known as the rifampicin resistance determining region (RRDR). The RRDR is surrounded by 12 amino acids, 11 of which have been linked to RIF mutations. The mutations in the RRDR usually result in an amino acid substitution that has an associated compact side chain with a larger amino acid and compact side chain. The inflexibility of rifampicin prevents it from being able to bind to the mutated beta subunit of RNAP. PMID: 26038512 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Mycobacterium tuberculosis complex rpoB gene rifAMPin resistance mutation
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-05-03
Construct for LOINC Short Name
MTB cmplx rpoB RIF mut

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP267160-2

Language Variants Get Info

Tag Language Translation
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis complex rpoB-gen rifampicineresistentie-mutatie
it-IT Italian (Italy) Mycobacterium tuberculosis complex, gene rpoB rifampina resistente
Synonyms: Gene rpoB di complesso di micobatteri della tuberc
zh-CN Chinese (China) 结核分枝杆菌复合菌群 rpoB 基因利福平耐药性突变
Synonyms: 结核分枝杆菌复合菌群（结核分支杆菌复合体、结核分支杆菌复合群、结核分支杆菌复合菌群、结核分枝杆菌复合体、结核分枝杆菌复合物、结核分枝杆菌结核菌群、结核杆菌复合菌群）基因利福平（甲哌力复霉素、利福霉素、立复霉素、立放平）耐药性（抗性、耐性、耐药、抗药、抗药性、耐受、耐药型）突变
es-ES Spanish (Spain) Mutación Gen rpoB de resistencia a rifampicina de Mycobacterium tuberculosis
fr-CA French (Canada) Mycobacterium complexe tuberculosis résistance à la rifampicine rpoB gène mutation