Version 2.78

Description

Fluorquinolones are among most beneficial drugs used to treat multi-drug resistant Mycobacterium tuberculosis (MDR-TB) infections. The fluorquinolones affect the activity of DNA gyrase by reducing the cell's ability for DNA replication and transcription. DNA gyrase in Mycobacterium tuberculosis (TB) is made of two subunits that are encoded by gyrA and gyrB. Mutations in the gyrA quinolone resistance-determining region (QRDR) are responsible for causing most of the drug resistance of TB to the fluoroquinolones. The gyrB mutations have a much smaller impact on TB resistance to the fluoroquinolones. PMID: 26763957 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Mycobacterium tuberculosis gyrA gene fluoroquinolone resistance mutation
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-06-28
Construct for LOINC Short Name
MTB gyrA fluoroquin res mut

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP267987-8

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Mutación del gen gyrA de Mycobacterium tuberculosis resistente a la fluoroquinolona
it-IT Italian (Italy) Mycobacterium tuberculosis, gene gyrA fluorochinolone resistente
zh-CN Chinese (China) 结核分枝杆菌 gyrA 基因氟喹诺酮耐药性突变
Synonyms: 结核分枝杆菌（结核分支杆菌、结核杆菌、结核菌） gyrA 基因氟喹诺酮（氟喹诺酮类药物、氟喹诺酮类、氟化苯酚酮）耐药性（抗性、耐性、耐药、抗药、抗药性、耐受、耐药型）突变
nl-NL Dutch (Netherlands) Mycobacterium tuberculosis gyrA-gen fluorchinolonresistentie