Version 2.78

Description

Trimethylamine N-oxide (TMAO) is a colorless amine oxide that is produced from choline, betaine, and carnitine by gut microbial metabolism. Recently, elevated plasma TMAO levels in humans have been associated with risk for serious adverse cardiovascular incidents and death. Diet, the composition of gut microbial flora, and liver flavin monooxygenase activity all affect the plasma levels of TMAO. Foods that contain choline, lecithin, and carnitine, including red meat, eggs, dairy products, and salt-water fish, are sources of TMAO. TMAO alters cholesterol and bile metabolism, activates inflammatory pathways, and promotes foam cell formation. It is strongly suspected in mediating the development of type-2 diabetes mellitus. TMAO also increases with decreasing kidney function, and is associated with an increased risk of death in patients with chronic kidney disease. Treatments being explored to lower TMAO include broad-spectrum antibiotics to eliminate TMAO producing bacteria, the promotion of the growth of bacteria that utilize TMAO as a substrate, and the development of target-specific molecules. PMID: 27834801 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Trimethylamine N-oxide
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-08-07
Construct for LOINC Short Name
TMAO

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Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) N-óxido de trimetilamina
it-IT Italian (Italy) Trimetilammina N-ossido
zh-CN Chinese (China) 三甲基胺 N-氧化物
Synonyms: 氧化三甲胺;氧化三甲胺;三甲基胺N氧化物;CAS 62637-93-8