Version 2.78

Description

The RET gene (ret proto-oncogene) [HGNC Gene ID:9967] is located on chromosome 10q11.2. This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008] [NCBI Gene ID:5979] Source: National Center for Biotechnology Information (NCBI) Gene

Basic Part Properties

Part Display Name
RET gene rearrangements
Part Type
Component (Describes the core component or analyte measured)
Created On
2018-10-26
Construct for LOINC Short Name
RET gene rearrange

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP269797-9

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) RET 基因重排
Synonyms: RET 基因重排（重组）;RET 原癌基因;RET;Ret;PTC;RET51;RET9;c-Ret;CDHF12;CDHR16;HSCR1;MEN2A;MEN2B;MTC1;RET-ELE1;RET proto-oncogene
es-ES Spanish (Spain) Reordenamiento del gen RET
it-IT Italian (Italy) Riorganizzazioni del gene RET
nl-NL Dutch (Netherlands) RET-genherschikking
Synonyms: RET-gentranslocatie