LP28525-1
Naloxone
Active
Description
Naloxone is a pure opioid antagonist and, when taken at recommended doses, has no physiological effects in the absence of an opioid agonist. Intravenous naloxone becomes effective within two minutes of injection, but oral or sublingual naloxone has little effect due to its poor absorption. Therefore, intravenous naloxone is used to treat opioid overdose, and it is used as a sublingual combination with buprenorphine, an opioid agonist-antagonist used to treat chronic opioid-dependence, to lower buprenorphine's abuse potential as follows: when the combination is taken sublingually as prescribed, naloxone exerts little effect and buprenorphine's effects predominate; however, if crushed and injected intravenously, naloxone's antagonist properties reverse the agonist effects of buprenorphine and can precipitate withdrawal. PMID: 19368419 Nalaxone levels along with its inactive metabolite, naloxone-3-glucuronide (N3G), may be measured to monitor compliance or identify illicit opioid drug use. Source: Regenstrief LOINC, PMID: 19368419
Basic Part Properties
- Part Display Name
- Naloxone
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2001-08-27
- Construct for LOINC Short Name
- Naloxone
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Language Variants Get Info
Tag | Language | Translation |
---|---|---|
zh-CN | Chinese (China) | 钠洛酮 Synonyms: C19H21NO4; |
fr-CA | French (Canada) | Naloxone |
et-EE | Estonian (Estonia) | Naloksoon |
es-ES | Spanish (Spain) | Naloxona |
it-IT | Italian (Italy) | Naloxone |
tr-TR | Turkish (Turkey) | Nalokzon |
ru-RU | Russian (Russian Federation) | Налоксон |
nl-NL | Dutch (Netherlands) | naloxon |
fr-BE | French (Belgium) | Naloxone |
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