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Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. PMID: 21214559 Source: Regenstrief LOINC, PMID: 2121455

Basic Part Properties

Part Display Name
Ganglioside GQ1b
Part Type
Component (Describes the core component or analyte measured)
Created On
Construct for LOINC Short Name
GQ1b Gangl

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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 神经节苷脂 GQ1b
Synonyms: GQ1b;神经节糖苷 GQ1b
fr-CA French (Canada) Ganglioside GQ1b
et-EE Estonian (Estonia) Gangliosiid GQ1b
es-ES Spanish (Spain) Gangliósido GQ1b
it-IT Italian (Italy) Ganglioside GQ1b
tr-TR Turkish (Turkey) Gangliozid GQ1b
ru-RU Russian (Russian Federation) Ганглиозид GQ1b
nl-NL Dutch (Netherlands) ganglioside GQ1b
fr-BE French (Belgium) Ganglioside GQ1b