LP28780-2
Islet cell 512
Active
Description
Islet cell antigen (ICA) 512 is a receptor-tyrosine phosphatase-like protein associated with the secretory granules of neuroendocrine cells. ICA-512 is also known as protein tyrosine phosphatase-IA2 (PTP-IA2) or tyrosine phosphatase (IA2). It is an autoantigen of type 1 diabetes. This is NOT the same as pancreatic islet cell. Studies on type-1 diabetic patient's relatives found that the development of one or more islet autoantibodies (including IA-2 antibody) was an early indicator of the relatives' progression to type-1 diabetes. Autoantibody profiles identifying patients destined to develop type-1 diabetes are usually detectable before age three. One study found that for relatives seropositive for IA-2 antibody, the likelihood of developing type-1 diabetes mellitus within five-years was 65.3%. Some type-1 diabetic patients are originally diagnosed as having type-2 diabetes due to symptom onset in adulthood, societal obesity, and initial insulin-independence. Detection of one or more islet auto-antibodies (including IA-2) may be used to distinguish these patients with "latent autoimmune diabetes" from type-2 diabetics. Source: Regenstrief Institute
Basic Part Properties
- Part Display Name
- Islet cell 512
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2002-05-03
- Construct for LOINC Short Name
- Islet Cell512
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 岛细胞 512 Synonyms: IA-2; |
| fr-CA | French (Canada) | ICA 512 d'îlots de Langerhans |
| es-ES | Spanish (Spain) | Célula de los islotes 512 |
| it-IT | Italian (Italy) | Isola 512 cellula |
| tr-TR | Turkish (Turkey) | Adacık hücresi 512 |
| ru-RU | Russian (Russian Federation) | Островковая клетка 512 |
| nl-NL | Dutch (Netherlands) | islet antigeen-2 Synonyms: IA-2 |
| fr-BE | French (Belgium) | ICA 512 d'îlots de Langerhans |
| pl-PL | Polish (Poland) | Komórki wyspowe 512 Synonyms: Antygen 512 komórek wyspowych |
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright