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4-Hydroxyproline, or hydroxyproline (C 5 H 9 O 3 N), is an uncommon amino acid, abbreviated as HYP. Hydroxyproline differs from proline by the presence of a hydroxyl (OH) group attached to the C (gamma) atom.

Proline hydroxylation requires ascorbic acid (vitamin C). The most obvious, first effects (gingival and hair problems) of absence of ascorbic acid in humans come from the resulting defect in hydroxylation of proline residues of collagen, with reduced stability of the collagen molecule, causing scurvy.
Increased serum and urine levels of hydroxyproline have also been demonstrated in Paget's disease. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See for details. Source: Wikipedia, Hydroxyproline (Wikipedia)

A hydroxylated form of the amino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation. Source: National Library of Medicine, MeSH 2006

Hydroxyproline is a hydrophilic amino acid with uncharged polar groups and is a major component of collagen. Increased with hydroxyprolinemia and iminoglycinuria. Decreased with chronic Vitamin C deficiency. (Information from ARUP Laboratories 9/14/06) Source: Regenstrief Institute

Basic Part Properties

Part Display Name
Hydroxyproline Free
Part Type
Component (Describes the core component or analyte measured)
Created On
Construct for LOINC Short Name
OH-Proline Free

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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 羟基脯氨酸.游离型
Synonyms: 游离 OH-脯氨酸;游离型 OH-脯氨酸;游离型羟基脯氨酸;游离型羟脯氨酸;游离羟基脯氨酸;游离羟脯氨酸;羟基脯氨酸.游离;羟脯氨酸.游离;羟脯氨酸.游离型
fr-CA French (Canada) Hydroxyproline.libre
et-EE Estonian (Estonia) Hüdroksüproliin.vaba
es-ES Spanish (Spain) hidroxiprolina libre
it-IT Italian (Italy) Idrossiprolina.libera
Synonyms: Idrossiprolina Libera
tr-TR Turkish (Turkey) Hidroksiprolin.serb
ru-RU Russian (Russian Federation) Гидроксипролин.свободный
nl-NL Dutch (Netherlands) hydroxyproline.vrij
fr-BE French (Belgium) Hydroxyproline.libre