LP30736-0
Homocysteine cysteine disulfide
Active
Description
Homocystine is the double-bonded form of homocysteine, but it occurs only transiently before being converted to the harmless cystathionine via a vitamin B6-dependent enzyme. Homocystine and homocysteine-cysteine mixed disulfide account for >98% of total homocysteine in plasma from healthy individuals. PMID: 11592966 Oxidation of low-density lipoprotein (LDL) is thought to be a major factor in the pathophysiology of atherosclerosis. Elevated plasma homocysteine is an accepted risk factor for atherosclerosis, and may act through LDL oxidation, although this is controversial. However, the major thiol in plasma is cysteine, which is present at concentrations approximately 10 times greater than homocysteine; therefore homocystine in plasma is insignificant, and consequently homocystine is unlikely to influence LDL oxidation in vivo. PMID: 14732479 Increasing evidence supports a role for an elevation of homocysteine in schizophrenia. It has been demonstrated that neural tube defects are related to a genetic defect in homocysteine metabolism. Sufficient intake of folic acid is believed to reduce this risk by enhancing methylation of homocysteine and its conversion to methionine, thereby compensating for this genetic defect. Plasma homocysteine levels are elevated when folate levels are in the lower half of the normal range. PMID: 16143442 Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database ,
Reference Information
| Type | Source | Reference |
|---|---|---|
| Article | NCBI PubMed | Sengupta S, Wehbe C, Majors AK, Ketterer ME, DiBello PM, Jacobsen DW. Relative roles of albumin and ceruloplasmin in the formation of homocystine, homocysteine-cysteine-mixed disulfide, and cystine in circulation. J Biol Chem. 2001 Dec 14;276(50):46896-904. Epub 2001 Oct 9. PubMed PMID: 11592966. Link to PubMed |
Basic Part Properties
- Part Name
- Homocysteine cysteine disulfide
- Part Display Name
- Homocysteine cysteine disulfide
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2002-09-24
- Construct for LOINC Short Name
- Hycs-Cys diS
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 同型半胱氨酸-半胱氨酸二硫化物 Synonyms: Hcys-Cys diS; |
| es-ES | Spanish (Spain) | Homocisteína cisteína disulfuro |
| it-IT | Italian (Italy) | Omocisteina cisteina, disolfuro Synonyms: Disolfuro omocisteina cisteina |
| tr-TR | Turkish (Turkey) | Homosistein sistein disülfür |
| ru-RU | Russian (Russian Federation) | Гомоцистеин цистеин дисульфид |
| fr-BE | French (Belgium) | Bisulfure de cystéine homocystéine |
| fr-CA | French (Canada) | Bisulfure de cystéine homocystéine |
| nl-NL | Dutch (Netherlands) | homocysteïne cysteïne disulfide |
| el-GR | Greek (Greece) | Δισουλφιδικός δεσμός κυστεΐνης-ομοκυστεΐνης Synonyms: Δισουλφιδικός δεσμός κυστεΐνης-ομοκυστεΐνης |
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