Version 2.77

Description

Bile acids (BAs) play a primary role in digesting dietary fats. Primary BAs are produced in the liver by either the classic or alternative pathway. CYP7A1 controls the production of primary BAs in the liver. The primary BAs (chenodeoxycholic acid and cholic acid) are conjugated to either glycine or taurine to create conjugated primary BAs, which are stored in the gallbladder. Once released into the intestinal circulation, primary BAs are modified by gut bacteria (e.g., deconjugated) to form secondary BAs. Secondary BAs are actively reabsorbed in the terminal ileum, and travel back to the liver through the portal circulation. PMID: 28249284

Different disorders are associated with various patterns of primary and secondary BA levels. Examples of disorders and their associated BA patterns include:
Disorders of BA synthesis (information from PMID: 18577977):
1) Inborn errors of bile acid synthesis including cerebrotendinous xanthomatosis, Zellweger syndrome, and a variety of other enzyme deficiencies - low or absent BAs
2) Bile acid conjugation defects - increased levels of unconjugated cholic and deoxycholic acid, lack of chenodeoxycholic acid

Disorders of BA metabolism (information from PMID: 28249284):
1) Inflammatory bowel disease - reduced deconjugation by gut bacteria, lower levels of secondary BAs
2) Irritable bowel syndrome - reduced deconjugation, increased levels of primary conjugated BAs, lower levels of secondary BAs
3) Short bowel syndrome - reduced levels of secondary and tertiary BAs
4) Obesity - lower levels of both primary BAs Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Bile acid pattern
Part Type
Component (Describes the core component or analyte measured)
Created On
2002-12-13
Construct for LOINC Short Name
Bile Ac Pattern

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP30845-9
ConceptMap translate
https://fhir.loinc.org/ConceptMap/$translate?system=http://loinc.org&code=LP30845-9

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 胆汁酸模式
Synonyms: 胆汁酸模式(模式特征、特征模式、图谱、式样、组份、组分、成员)
fr-CA French (Canada) Profil acide biliaire
es-ES Spanish (Spain) Patrón de ácidos biliares
it-IT Italian (Italy) Acido biliare, profilo
Synonyms: Profilo acidi biliari
tr-TR Turkish (Turkey) Safra asidi patterni
ru-RU Russian (Russian Federation) Желчная кислота паттерн
Synonyms: Желчные кислоты профиль
nl-NL Dutch (Netherlands) galzurenprofiel
fr-BE French (Belgium) Profil acide biliaire