Version 2.78

Description

Paroxsmal nocturnal hemoglobinuria (PNH) is a condition that causes hemolytic anemia, bone marrow failure, and a proclivity to develop thrombosis. PNH occurs when the PIG-A gene of bone marrow stem cells undergoes mutation. Stems cells develop into erythrocytes (RBCs), white blood cells (WBCs), platelets, and mature cells that contain the PIG-A gene mutation, and as a result, lack a sufficient number of glycosylphosphatidylinositol-anchored protein (GPI-AP). The GPI-APs have various roles, some of which are to help to prevent RBC destruction, fight infection, and promote thrombosis.[https://www.hopkinsmedicine.org/kimmel_cancer_center/types_cancer/paroxysmal_nocturnal_hemoglobinuria_PNH.html] CD14, 16, 24, and 59 are GPI-linked proteins that are used as markers for the presence of GPI, as is fluorescent aerolysin (FLAER), which binds to GPI-APs. Patients with PNH lack sufficient GPIs and therefore have reduced expression of these cell markers and FLAER compared to patients without PNH. Patients with complete loss of CD59 are more likely to have hemolysis compared to patients with partial loss of CD59. Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Erythrocytes.CD59 deficient
Part Type
Component (Describes the core component or analyte measured)
Created On
2003-03-05
Construct for LOINC Short Name
Erythrocytes.CD59 deficient

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP31589-2

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 红细胞.CD59 缺乏型
Synonyms: CD59 缺乏型 RBC;CD59 缺乏型红细胞;RBC.CD59 缺乏型
fr-CA French (Canada) Érythrocytes.CD59 déficients
et-EE Estonian (Estonia) Erütrotsüüdid.CD59 defitsiitne
es-ES Spanish (Spain) Eritrocitos CD59 deficientes
it-IT Italian (Italy) Eritrociti.deficit CD59
Synonyms: RBC deficit CD59
tr-TR Turkish (Turkey) Eritrositler.CD59 eksik
ru-RU Russian (Russian Federation) Эритроциты.CD59 дефектный
nl-NL Dutch (Netherlands) erytrocyten.CD59-deficiënt
Synonyms: erytrocyten.CD59 deficient
fr-BE French (Belgium) Érythrocytes.CD59 déficients
pl-PL Polish (Poland) Erytrocyty CD59 ujemne