LP31707-0
Neuronal nuclear type 3
Active
Description
Neuronal nuclear type 3 Ab (ANNA-3) is one of three neuronal nuclear paraneoplastic antibodies that primarily binds to the nuclei of cerebellar Purkinje neurons and to renal glomerular podocytes. Symptoms of the presence of ANNA-3 include sensory or sensorimotor neuropathies, cerebellar ataxia, myelopathy, brain stem and limbic encephalopathy.It's presence in serum is most commonly indicative of a small-cell malignant tumor, most of which are primary tumors of the lung.Fluorescent staining patterns are used to distinguish ANNA-3 from the other two neuronal nuclear types, ANNA-1 and ANNA-2. ANNA-3 binds the nuclei of Purkinje neurons in the cerebellar cortex more than the molecular neurons, and does not bind granular neurons. ANNA-3 binds only the nuclei of indentate neurons, while ANNA-1 and ANNA-2 bind both the nuclei and cytoplasm of all neurons. ANNA-3 binds the nuclei of glomuerular podocytes in of the renal cortex in 10 of 11 sera. For the same cell type, ANNA-2 binds both the nuclei and cytoplasm in 8 of 32 sera, and ANNA-1 does not bind the podocytes at all. PMID: 11558786 Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- Neuronal nuclear type 3
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2003-04-22
- Construct for LOINC Short Name
- Hu3
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 神经元细胞核 3 型 Synonyms: ANNA 3; |
| fr-CA | French (Canada) | Neuronal nucléaire de type 3 |
| es-ES | Spanish (Spain) | Neuronal nuclear tipo 3 |
| it-IT | Italian (Italy) | Nucleare neuronale tipo 3 |
| tr-TR | Turkish (Turkey) | Nöronal nükleer tip 3 |
| ru-RU | Russian (Russian Federation) | Нейрональный ядерный тип 3 |
| nl-NL | Dutch (Netherlands) | neuronaal nucleair type 3 |
| fr-BE | French (Belgium) | Type 3 neuronal nucléaire |
| pl-PL | Polish (Poland) | Typ 3 neuronalny jądrowy |
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