LP31885-4
SDHB gene
Active
Description
The SDHB gene (succinate dehydrogenase complex, subunit B, iron sulfur (Ip)) [HGNC Gene ID:10681] is located on chromosome 1p36.1-p35. Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008] [NCBI Gene ID:6390] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Name
- SDHB gene
- Part Display Name
- SDHB gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2003-08-08
- Construct for LOINC Short Name
- SDHB gene
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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//fhir.loinc.org/ConceptMap/$translate?system=http: //loinc.org&code=LP31885-4
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | SDHB 基因 Synonyms: IP; |
| et-EE | Estonian (Estonia) | SDHB geen |
| es-ES | Spanish (Spain) | Gen SDHB |
| it-IT | Italian (Italy) | SDHB, gene Synonyms: Gene SDHB |
| tr-TR | Turkish (Turkey) | SDHB geni |
| ru-RU | Russian (Russian Federation) | SDHB ген |
| nl-NL | Dutch (Netherlands) | SDHB-gen Synonyms: SDHB gen |
LOINC Copyright
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