Version 2.77

Description

The SDHB gene (succinate dehydrogenase complex, subunit B, iron sulfur (Ip)) [HGNC Gene ID:10681] is located on chromosome 1p36.1-p35. Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008] [NCBI Gene ID:6390] Source: National Center for Biotechnology Information (NCBI) Gene

Reference Information

Type Source Reference
Webcontent Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. Link to OMIM

Basic Part Properties

Part Display Name
SDHB gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2003-08-08
Construct for LOINC Short Name
SDHB gene

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP31885-4
ConceptMap translate
https://fhir.loinc.org/ConceptMap/$translate?system=http://loinc.org&code=LP31885-4

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) SDHB 基因
Synonyms: IP;SDH;SDH1;SDHIP;琥珀酸脱氢酶复合体, 亚单位 B, 铁硫;琥珀酸脱氢酶复合体, 亚基 B, 铁硫
et-EE Estonian (Estonia) SDHB geen
es-ES Spanish (Spain) Gen SDHB
it-IT Italian (Italy) SDHB, gene
Synonyms: Gene SDHB
tr-TR Turkish (Turkey) SDHB geni
ru-RU Russian (Russian Federation) SDHB ген
nl-NL Dutch (Netherlands) SDHB-gen
Synonyms: SDHB gen