Version 2.78

Description

The ACTH stimulation test (also called the cosyntropin test, tetracosactide test or Synacthen test) is a medical test usually ordered and interpreted by endocrinologists to assess the functioning of the adrenal glands stress response by measuring the adrenal response to adrenocorticotropic hormone (ACTH). ACTH is a hormone produced in the pituitary gland that stimulates the adrenal glands to release cortisol.

During the test, a small amount of synthetic ACTH is injected, and the amount of cortisol, and sometimes aldosterone, the adrenals produce in response is measured. This test may cause mild to moderate side effects in some individuals.

This test is used to diagnose or exclude primary and secondary adrenal insufficiency, Addison's disease and related conditions. In addition to quantifying adrenal insufficiency, the test can distinguish whether the cause is adrenal (low cortisol and aldosterone production) or pituitary (low ACTH production). The ACTH stimulation test is recognized as the gold standard assay of adrenal insufficiency, although this test is primarily used to determine the presence of Addison's disease and pituitary impairment. If the test does not show Addison's, the test interpreter may see it as showing the adrenal glands are working, not recognizing any degree of adrenal insufficiency between Addison's (the worst degree of adrenal insufficiency) and healthy adrenal function.[citation needed] The test is extremely sensitive (97% at 95% specificity) to primary adrenal insufficiency, but less so to secondary adrenal insufficiency (57-61% at 95% specificity); while secondary adrenal insufficiency may thus be dismissed by some interpreters on the basis of the test, additional testing may be called for if probability of secondary adrenal insufficiency is particularly high.

Adrenal insufficiency is a potentially life-threatening condition. Treatment should be initiated as soon as the diagnosis is confirmed, or sooner if the patient presents in apparent adrenal crisis Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Basic Part Properties

Part Display Name
ACTH stimulation test using IV corticosteroids
Part Type
Component (Describes the core component or analyte measured)
Created On
2003-08-22
Construct for LOINC Short Name
ACTH Stim IV Pnl

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP31925-8

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) ACTH刺激试验^静脉注射250 ug促肾上腺皮质激素组套
Synonyms: ACTH刺激试验^静脉注射250 ug促肾上腺皮质激素组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）;ACTH刺激试验^250 ug 促肾上腺皮质激素 IV 医嘱组;ACTH刺激试验^250 ug 促肾上腺皮质激素 静注 医嘱组;ACTH刺激试验^250 ug 促肾上腺皮质激素 静脉注射 医嘱组;ACTH刺激试验^250微克 促肾上腺皮质激素 IV 医嘱组;ACTH刺激试验^250微克 促肾上腺皮质激素 静注 医嘱组;ACTH刺激试验^250微克 促肾上腺皮质激素 静脉注射 医嘱组;A
fr-CA French (Canada) Essai de stimulation de l'ACTH^250 ug voie intraveineuse
es-ES Spanish (Spain) Prueba de estimulación de ACTH con corticosteroides intravenosos
it-IT Italian (Italy) ACTH, test di provocazione con corticosteroidi EV
Synonyms: Test di stimolo dell''ACTH con corticosteroidi EV;
tr-TR Turkish (Turkey) ACTH stimulation test using IV kortikosteroidler
ru-RU Russian (Russian Federation) АКТГ стимуляция тест с применением ВВ кортикостероидов
nl-NL Dutch (Netherlands) ACTH-stimulatie-test met behulp van IV corticosteroïden
Synonyms: ACTH stimulatie test met behulp van IV corticosteroiden
fr-BE French (Belgium) Essai de stimulation de l'ACTH^250 ug corticostéroides voie intraveineuse
Synonyms: Simulation de l''ACTH.250µg corticostéroïdes intraveineuse