LP32135-3
Prealbumin
Active
Description
Transthyretin (TTR) (originally called prealbumin or thyroxine-binding prealbumin) is a homotetrameric unglycosylated tryptophan rich protein that carries the thyroid hormones T3 and T4, and retinol in serum and CSF. Synthesized in hepatocytes, TTR and has a molar mass of 55000 daltons. At a pH of 8.6, an electrophoretic band appears prior to albumin in a relative amount of < 2.5 % due to its greater rate of diffusion to the anode. Its function is to bind and transport low molecular weight retinol-binding proteins, preventing their glomerular filtration. 30 50 % of circulating TTR is complexed by retinol-binding protein. Additionally, it binds and transports thyroxine (T4), nevertheless its affinity to this hormone is less than that of thyroxine binding globulin. TTR is decreased in hepatocellular synthesis caused by acute liver damage, or dietary protein deficiency, and because of its short half life (approximately 2 days) is used as a surrogate marker of nutritional status. TTR is also a negative acute phase reactive protein and levels decrease in inflammatory states. Levels can be elevated in chronic renal failure, high concentrations of corticosteroids, and Hodgkin's disease. TTR misfolding and aggregation is known to be associated with the amyloid diseases, senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC) [Tietz] Source: Regenstrief LOINC, Wikipedia: Transthyretin
Basic Part Properties
- Part Display Name
- Prealbumin
- Part Type
- Divisors (Divisors only)
- Created On
- 2003-09-03
- Construct for LOINC Short Name
- Prealb
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP32135-3
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 前白蛋白 Synonyms: 前清蛋白 |
| et-EE | Estonian (Estonia) | prealbumiin |
| es-ES | Spanish (Spain) | Prealbumina |
| it-IT | Italian (Italy) | Prealbumina |
| tr-TR | Turkish (Turkey) | Prealbumin |
| ru-RU | Russian (Russian Federation) | Преальбумин |
| nl-NL | Dutch (Netherlands) | pre-albumine |
| pl-PL | Polish (Poland) | prealbumina |
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright