LP32397-9
Ab.IgG4
Active
Description
IgG4 is the least common subtype of IgG, and it has a variety of functions. In the context of allergic disease it is thought to have an immune-inhibitory role in preventing anaphylaxis and is commonly known as a "blocking" antibody. IgG4 binding to an allergen can compete with IgE-mediated binding, thereby inhibiting the activation of mast cells and basophils and IgE-mediated presentation to T-cells. Measuring IgG4 and its ratio to IgE has a role in monitoring allergen specific immunotherapy PMID: 26023323. IgG4 is also thought to have a role in autoimmunity and be involved in a less defined entity known as IgG4-Related Disease, a chronic immune-mediated fibroinflammatory disorder that often manifests with tumor-like masses .[https://www.merckmanuals.com/professional/musculoskeletal-and-connective-tissue-disorders/igg4-related-disease/igg4-related-disease] Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- IgG4
- Part Type
- Suffix
- Created On
- 2003-09-03
- Construct for LOINC Short Name
- IgG4
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP32397-9
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 抗体.IgG4 Synonyms: Ab.IgG4; |
| fr-CA | French (Canada) | , IgG4 |
| et-EE | Estonian (Estonia) | antikehad.IgG4 |
| es-ES | Spanish (Spain) | IgG4 |
| it-IT | Italian (Italy) | Ab.IgG4 Synonyms: Anticorpi IgG4 |
| tr-TR | Turkish (Turkey) | Ab.IgG4 Synonyms: Ak.IgG4 |
| ru-RU | Russian (Russian Federation) | Ат.IgG4 |
| nl-NL | Dutch (Netherlands) | As.IgG4 |
| fr-BE | French (Belgium) | Anticorps. IgG4 |
| pl-PL | Polish (Poland) | Ab.IgG4 |
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