LP35095-6
inFLIXimab
Active
Description
Infliximab is a genetically engineered immunoglobulin 1 murine-human chimeric monoclonal antibody against tumor necrosis factor alpha (TNFα). The murine portion is the part of the antibody that binds to TNFα while the human portion preserves functional immune capacity. Infliximab is used to treat Crohn's disease and, in particular, in treating the closure of intestinal or perianal fistulas in patients with acute intestinal involvement who have been unresponsive to other treatments. TNFα is a cytokine that acts to increase the inflammatory process in CD, RA, psoriasis and spondylarthropathy. The primary mechanism of infliximab is to combine with the inactivate soluble transmembrane TNFα. However, infliximab also modulates TNFα-producing cells through complement fixation of antibody-dependent T lymphocytes and monocytes by binding them to the IgG1 fc portion of infliximab. There is also a subsequent down-regulation of other inflammation-producing cytokines and a reduction of the level of chemokines and endothelial adhesion molecules. Negative side effects of infliximab include fibrostenosing CD and sepsis. PMID: 18360638 Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- inFLIXimab
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2005-02-17
- Construct for LOINC Short Name
- inFLIXimab
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP35095-6 - ConceptMap translate
- https:
//fhir.loinc.org/ConceptMap/$translate?system=http: //loinc.org&code=LP35095-6
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 英利昔单抗 Synonyms: Infliximab 单抗; |
| fr-CA | French (Canada) | Infliximab Synonyms: #REF! |
| et-EE | Estonian (Estonia) | Infliksimaab |
| es-ES | Spanish (Spain) | Infliximab |
| it-IT | Italian (Italy) | Infliximab |
| tr-TR | Turkish (Turkey) | İnfliksimab |
| ru-RU | Russian (Russian Federation) | Инфликсимаб |
| nl-NL | Dutch (Netherlands) | infliximab |
| fr-BE | French (Belgium) | Infliximab |
LOINC Copyright
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