LP35592-2
Mononuclear cells.atypical
Active
Descriptions
A Peripheral Blood Mononuclear Cell (PBMC) is a blood cell having a round nucleus, such as a lymphocyte or a monocyte. These blood cells are a critical component in the immune system to fight infection and adapt to intruders. The lymphocyte population consists of T cells (CD4 and CD8 positive ~75%), B cells and NK cells (~25% combined).
These cells are often extracted from whole blood using ficoll, a hydrophilic polysaccharide that separates layers of blood, with monocytes and lymphocytes forming a buffy coat under a layer of plasma. This buffy coat contains the PBMCs. Additionally, PBMC can be extracted from whole blood using a hypotonic lysis which will preferentially lyse red blood cells. This method results in neutrophils and other polymorphonuclear (PMN) cells which are important in innate immune defense to be obtained.
PBMCs are widely used in research and clinical uses every day. HIV research uses them because PBMCs include CD4+ cells, the cells HIV infects.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Mononuclear cell
Atypical mononuclear cells are morphologically abnormal lymphocytes or monocytes that may appear in a blood after immunizations or surgery, during infections, or at the onset of autoimmune diseases. Findings include primitive nuclei with a diffuse chromatin pattern and nucleoli, lobulated nuclei, and hyper-basophilic cytoplasm. The cells vary greatly in size and shape. Large numbers of atypical mononuclear cells can be seen with viral infections, including infectious mononucleosis (Epstein-Barr virus), infectious hepatitis (Hepatitis A virus) and bronchitis (adenovirus). Smaller numbers of atypical lymphocytes are seen in many other viral infections and in some bacterial and protozoan infections. Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- Mononuclear cells.atypical
- Part Display Name
- Mononuclear cells atypical
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2005-04-01
- Construct for LOINC Short Name
- Atypical Mononuc
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP35592-2
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 单个核细胞.异型 Synonyms: 不典型单个核细胞; |
| fr-CA | French (Canada) | Cellules mononucléaires.atypiques |
| es-ES | Spanish (Spain) | Células mononucleares atípicas |
| it-IT | Italian (Italy) | Cellule mononucleari.atipiche Synonyms: Cellule mononucleari atipiche |
| tr-TR | Turkish (Turkey) | Mononükleer hücreler.atipik |
| ru-RU | Russian (Russian Federation) | Мононуклеарные клетки.атипичные |
| nl-NL | Dutch (Netherlands) | mononucleaire cellen.atypisch |
| fr-BE | French (Belgium) | Cellules mononucléaires.atypiques |
| pl-PL | Polish (Poland) | Mononuklearne komórki.atypowe Synonyms: Mononuklearne komórki atypowe |
LOINC Copyright
Copyright © 2024 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://