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Cocaine is an alkaloid of Erythroxylon coca that is grown in the northern South American Andes, India, Africa and Java. It is used medicinally as a local anesthetic and vasoconstrictor in nasal surgery and to dilate pupils. Because cocaine is a powerful central nervous system stimulant it is among the most abused drugs. Cocaine abuse can lead to sudden death due to cardiotoxicity or the sequential development of hyperthermia, agitated delirium and respiratory arrest. Cocaine is metabolized in the liver to inactive benzoylecgonine (BZE). BZE is pharmacologically inactive and has a longer half-life than its parent drug cocaine. It is the substance most tested for when investigating suspected cocaine abuse. Cocaethylene (CE) is produced in the liver in the presence of ethanol and has been shown to have similar stimulatory effects as cocaine in animal studies.(Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics, Seventh Edition) Cocaethylene is toxic to the myocardium. PMID: 8761012 Source: Regenstrief LOINC

Benzoylecgonine is the major metabolite of cocaine. It is a biological metabolite with a stable structure that resists hydrolysis, both in the body and in the environment. Benzoylecgonine remains in the body for a few days and is commonly used as a marker in drug tests. [PMCID:1929267] PMID: 27224254 Source: Regenstrief LOINC

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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 可卡因+苯甲酰芽子碱
Synonyms: 可卡因(古柯碱、柯卡因)+苯甲酰芽子碱
fr-CA French (Canada) Cocaïne+Benzoylecgonine
es-ES Spanish (Spain) Cocaina+Benzoilecgonina
it-IT Italian (Italy) Cocaina+Benzoilecgonina
tr-TR Turkish (Turkey) Kokain+Benzoilekgonin
ru-RU Russian (Russian Federation) Кокаин+Бензоилэкгонин
nl-NL Dutch (Netherlands) cocaïne + benzoylecgonine
fr-BE French (Belgium) Cocaïne+Benzoylecgonine