LP36048-4
Tigecycline
Active
Descriptions
Tigecycline is a broad-spectrum glycylcyline antibiotic and a semisynthetic tetracycline. It has activity against a broad range of Gram-positive, Gram-negative, atypical, anaerobic and antibiotic-resistant bacteria. This includes activity against MRSA, VRE and penicillin resistant Streptococcus pneumoniae. It is administered by intravenous infusion. Information from http://www.touchbriefings.com/pdf/2110/koulenti.pdf and http://www.uspharmacist.com/index.asp?page=ce/105130/default.htm. Source: Regenstrief Institute
Tiglylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycine Tiglylglycine is an intermediate product of the catabolism of isoleucine. An elevated level of tiglylglycine is identified in urine of patients with beta-ketothiolase deficiency or with disorders of propionate metabolism PMID: 7923765. Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.) Source: Human Metabolome Database, Tiglylglycine
Tigecycline (INN) is a glycylcycline antibiotic marketed under the brand name Tygacil. It was given a U.S. Food and Drug Administration (FDA) fast-track approval and was approved on June 17, 2005. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus and Acinetobacter baumannii. The New Delhi metallo-β-Lactamase multidrug-resistant Enterobacteriaceae has also shown susceptibility to tigecycline. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia
Basic Part Properties
- Part Display Name
- Tigecycline
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2005-09-13
- Construct for LOINC Short Name
- Tigecycline
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 替加环素 Synonyms: 替格环素 |
| fr-CA | French (Canada) | Tigécycline |
| et-EE | Estonian (Estonia) | Tigetsükliin |
| es-ES | Spanish (Spain) | Tigeciclina |
| it-IT | Italian (Italy) | Tigeciclina |
| tr-TR | Turkish (Turkey) | Tigesiklin |
| ru-RU | Russian (Russian Federation) | Тайгециклин |
| nl-NL | Dutch (Netherlands) | tigecycline |
| fr-BE | French (Belgium) | Tigécycline |
LOINC Copyright
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