Version 2.77

Descriptions

Part of HLA-B57 allele family that is associated with Abacavir hypersensitivity reaction (AHSR) Source: Regenstrief Institute

The human leukocyte antigen B (HLA-B) plays an important role in how the immune system recognizes and responds to pathogens. HLA-B belongs to a class of molecules that are found on the surface of most cells. These molecules are responsible for presenting peptides to immune cells. Peptides derived from normal human proteins are recognized as such, whereas foreign peptides derived from pathogens trigger an immune response. The antiretroviral medication abacavir specifically interacts with HLA-B*57:01 and alters the repertoire of self-peptides that are presented to T lymphocytes, which activates an immune reaction known as a hypersensitivity reaction. PMID: 24561393 See https://www.pharmgkb.org/gene/PA35056 for more information and dosing guidelines for drugs impacted by HLA-B genetic variation. Source: Clinical Pharmacogenetics Implementation Consortium

Basic Part Properties

Part Display Name
HLA-B*57:01
Part Type
Component (Describes the core component or analyte measured)
Created On
2005-09-13
Construct for LOINC Short Name
HLA-B*57:01

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP36049-2

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) HLA-B*57:01
Synonyms: HLA-B5701;HLA-B57;与阿巴卡韦超敏反应（ Abacavir hypersensitivity reaction，AHSR）相关联的 HLA-B57 等位基因家族的组成部分
fr-CA French (Canada) HLA-B*57:01
et-EE Estonian (Estonia) HLA-B5701
es-ES Spanish (Spain) HLA-B*57:01
it-IT Italian (Italy) HLA-B*57:01
tr-TR Turkish (Turkey) HLA-B*5701
ru-RU Russian (Russian Federation) HLA-B*5701
nl-NL Dutch (Netherlands) HLA-B*5701
fr-BE French (Belgium) HLA-B5701