LP36220-9
Insulin-like growth factor-I receptor
Active
Description
The Insulin-like Growth Factor 1 (IGF-1) Receptor is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth-promoting effect of this receptor. Mice carrying only one functional copy of igf1r are normal, but exhibit a ~15% decrease in body mass.
The IGF-1R is implicated in several cancers,[4][5] including both breast and prostate cancer. In some instances its anti-apoptotic properties allow cancerous cells to resist the cytotoxic properties of chemotheraputic drugs or radiotherapy. In breast cancer, where EGFR inhibitors such as erlotinib are being used to inhibit the EGFR signaling pathway, IGF-1R confers resistance by forming one half of a heterodimer (see the description of EGFR signal transduction in the erlotinib page), allowing EGFR signaling to resume in the presence of a suitable inhibitor. This process is referred to as crosstalk between EGFR and IGF-1R. It is further implicated in breast cancer by increasing the metastatic potential of the original tumour by inferring the ability to promote vascularisation.
Increased levels of the IGF-IR are expressed in the majority of primary and metastatic prostate cancer patient tumors.Evidence suggests that IGF-IR signaling is required for survival and growth when prostate cancer cells progress to androgen independence. In addition, when immortalized prostate cancer cells mimicking advanced disease are treated with the IGF-1R ligand, IGF-1, the cells become more motile.
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Source: Wikipedia, Wikipedia
Basic Part Properties
- Part Name
- Insulin-like growth factor-I receptor
- Part Display Name
- Insulin-like growth factor-I receptor
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2005-10-24
- Construct for LOINC Short Name
- IGF-IR
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 胰岛素样生长因子-I受体 Synonyms: IGF1R; |
| fr-CA | French (Canada) | Récepteur à facteur de croissance insulinomimétique-I |
| et-EE | Estonian (Estonia) | Insuliinisarnane kasvufaktori 1 retseptor |
| es-ES | Spanish (Spain) | Receptor del factor I de crecimiento tipo insulina |
| it-IT | Italian (Italy) | Fattore di crescita insulino-simile I, recettore Synonyms: Recettore del fattore di crescita insulino-simile |
| tr-TR | Turkish (Turkey) | İnsülin benzeri büyüme faktörü-I reseptörü |
| ru-RU | Russian (Russian Federation) | Инсулиноподобный ростовой фактор-I рецептор |
| nl-NL | Dutch (Netherlands) | insulin-like growth factor-I-receptor |
| fr-BE | French (Belgium) | Récepteur . facteur de croissance insulinomimétique-I Synonyms: IGF-I. Récepteur |
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