LP36229-0
CCND1 gene
Active
Description
The CCND1 gene (cyclin D1) [HGNC Gene ID:1582] is located on chromosome 11q13. The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008] [NCBI Gene ID:595] Source: National Center for Biotechnology Information (NCBI) Gene
Reference Information
| Type | Source | Reference |
|---|---|---|
| Webcontent | Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. | Link to OMIM |
Basic Part Properties
- Part Display Name
- CCND1 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2005-10-24
- Construct for LOINC Short Name
- CCND1 gene
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP36229-0 - ConceptMap translate
- https:
//fhir.loinc.org/ConceptMap/$translate?system=http: //loinc.org&code=LP36229-0
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | CCND1 基因 Synonyms: B 细胞 CLL; |
| et-EE | Estonian (Estonia) | CCND1 geen |
| es-ES | Spanish (Spain) | Gen CCND1 |
| it-IT | Italian (Italy) | CCND1, gene Synonyms: Gene CCND1 |
| tr-TR | Turkish (Turkey) | CCND1 geni |
| ru-RU | Russian (Russian Federation) | CCND1 ген |
| nl-NL | Dutch (Netherlands) | CCND1-gen Synonyms: CCND1 gen |
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