Version 2.78

Description

The MYC gene (v-myc avian myelocytomatosis viral oncogene homolog) [HGNC Gene ID:7553] is located on chromosome 8q24.21. The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008] [NCBI Gene ID:4609] Source: National Center for Biotechnology Information (NCBI) Gene

Reference Information

Type Source Reference
Webcontent Online Mendelian Inheritance in Man®Copyright OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University. Link to OMIM

Basic Part Properties

Part Display Name
MYC gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2005-10-24
Construct for LOINC Short Name
MYC gene

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP36232-4
ConceptMap translate
https://fhir.loinc.org/ConceptMap/$translate?system=http://loinc.org&code=LP36232-4

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) MYC 基因
Synonyms: v-myc myelocytomatosis viral oncogene homolog (avian);MYC;MRTL;bHLHe39;c-Myc;avian myelocytomatosis viral oncogene homolog;class E basic helix-loop-helix protein 39;myc proto-oncogene protein;myc-related translation/localization regulatory factor;proto-on
et-EE Estonian (Estonia) MYC geen
es-ES Spanish (Spain) Gen MYC
it-IT Italian (Italy) MYC, gene
Synonyms: Gene MYC
tr-TR Turkish (Turkey) MYC geni
ru-RU Russian (Russian Federation) MYC ген
nl-NL Dutch (Netherlands) MYC-gen
Synonyms: MYC gen