Version 2.78

Description

Bile acids (BAs) play a primary role in digesting dietary fats. Primary BAs are produced in the liver by either the classic or alternative pathway. CYP7A1 controls the production of primary BAs in the liver. The primary BAs (chenodeoxycholic acid and cholic acid) are conjugated to either glycine or taurine to create conjugated primary BAs, which are stored in the gallbladder. Once released into the intestinal circulation, primary BAs are modified by gut bacteria (e.g., deconjugated) to form secondary BAs. Secondary BAs are actively reabsorbed in the terminal ileum, and travel back to the liver through the portal circulation. PMID: 28249284

Different disorders are associated with various patterns of primary and secondary BA levels. Examples of disorders and their associated BA patterns include:
Disorders of BA synthesis (information from PMID: 18577977):
1) Inborn errors of bile acid synthesis including cerebrotendinous xanthomatosis, Zellweger syndrome, and a variety of other enzyme deficiencies - low or absent BAs
2) Bile acid conjugation defects - increased levels of unconjugated cholic and deoxycholic acid, lack of chenodeoxycholic acid

Disorders of BA metabolism (information from PMID: 28249284):
1) Inflammatory bowel disease - reduced deconjugation by gut bacteria, lower levels of secondary BAs
2) Irritable bowel syndrome - reduced deconjugation, increased levels of primary conjugated BAs, lower levels of secondary BAs
3) Short bowel syndrome - reduced levels of secondary and tertiary BAs
4) Obesity - lower levels of both primary BAs Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Bile acid fractions panel
Part Type
Component (Describes the core component or analyte measured)
Created On
2005-11-15
Construct for LOINC Short Name
Bile Acid Fract Pnl

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP36372-8

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 胆汁酸类成分组套
Synonyms: 胆汁酸分离医嘱组;胆汁酸分类医嘱组;胆汁酸分级医嘱组;胆汁酸鉴别医嘱组;胆汁酸分馏医嘱组;胆汁酸馏分医嘱组;分馏型胆汁酸组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）;胆汁酸成分（组分、组份、成份）医嘱组
es-ES Spanish (Spain) Panel ácidos biliares fraccionados
it-IT Italian (Italy) Acido biliare, panel frazionato
Synonyms: Panel frazionato acidi biliari
tr-TR Turkish (Turkey) Safra asidi fraksiyonlamış panel
ru-RU Russian (Russian Federation) Желчные кислоты фракционированные панель
nl-NL Dutch (Netherlands) galzuren fracties panel