LP410874-4
von Willebrand factor cleaving protease activity
Active
Description
von Willebrand factor (vWF) cleaving protease, or ADAMTS13, is a metalloprotease that cleaves vWF and thereby limits platelet aggregation and formation of microthrombi. vWF cleaving protease inhibitors can decrease the protease activity and/or more rapidly remove the enzyme from the circulation. Such inhibitors are one cause of thrombotic thrombocytopenic purpura (TTP), a disorder characterized by thrombocytopenia, anemia, fever, and neurologic and renal abnormalities. Idiopathic TTP is often due to anti-ADAMTS13 autoantibodies, while inherited TTP is an autosomal recessive disorder due to mutations in the ADAMTS13 gene that lead to impaired protease function. Work-up of patients with TTP can include vWF cleaving protease activity and, if that activity is low, inhibitor screen followed by quantification. PMID: 18756543 Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- von Willebrand factor cleaving protease activity
- Part Display Name
- von Willebrand factor (vWf) cleaving protease activity
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2019-07-05
- Construct for LOINC Short Name
- vWF Cp Act
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | von Willebrand 因子裂解蛋白酶活性 Synonyms: von Willebrand 因子（vWf 因子、 |
| it-IT | Italian (Italy) | von Willebrand, fattore attività proteasi di taglio Synonyms: Attività della proteasi di taglio del fattore di von Willebrand |
| fr-FR | French (France) | ADAMTS 13 activité |
| es-ES | Spanish (Spain) | Actividad de la proteasa de escisión del factor de von Willebrand |
| pl-PL | Polish (Poland) | Aktywność proteazy rozkładającej czynnik von Willebranda Synonyms: Aktywność ADAMTS13 |
| el-GR | Greek (Greece) | δραστικότητα πρωτεάσης διάσπασης παράγοντα Von Willebrand Synonyms: δραστικότητα πρωτεάσης διάσπασης παράγοντα Von Willebrand |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://