Version 2.77

Description

von Willebrand factor (vWF) cleaving protease, or ADAMTS13, is a metalloprotease that cleaves vWF and thereby limits platelet aggregation and formation of microthrombi. vWF cleaving protease inhibitors can decrease the protease activity and/or more rapidly remove the enzyme from the circulation. Such inhibitors are one cause of thrombotic thrombocytopenic purpura (TTP), a disorder characterized by thrombocytopenia, anemia, fever, and neurologic and renal abnormalities. Idiopathic TTP is often due to anti-ADAMTS13 autoantibodies, while inherited TTP is an autosomal recessive disorder due to mutations in the ADAMTS13 gene that lead to impaired protease function. Work-up of patients with TTP can include vWF cleaving protease activity and, if that activity is low, inhibitor screen followed by quantification. PMID: 18756543 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
von Willebrand factor (vWf) cleaving protease activity
Part Type
Component (Describes the core component or analyte measured)
Created On
2019-07-05
Construct for LOINC Short Name
vWF Cp Act

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP410874-4

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) von Willebrand 因子裂解蛋白酶活性
Synonyms: von Willebrand 因子（vWf 因子、血管性假血友病因子、血管性血友病因子）裂解蛋白酶活性
it-IT Italian (Italy) von Willebrand, fattore attività proteasi di taglio
Synonyms: Attività della proteasi di taglio del fattore di von Willebrand
es-ES Spanish (Spain) Actividad de la proteasa de escisión del factor de von Willebrand