LP410955-1
NUDT15 gene product metabolic activity interpretation
Active
Description
The NUDT15 (nudix hydrolase 15) gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Apr 2016][NCBI Gene ID: 55270] Source: National Center for Biotechnology Information (NCBI) Gene
Basic Part Properties
- Part Display Name
- NUDT15 gene product metabolic activity interpretation
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2019-07-22
- Construct for LOINC Short Name
- NUDT15 gene prod met act imp
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | NUDT15 基因产物新陈代谢活性解释 Synonyms: NUDT15 基因产物新陈代谢（代谢）活性解释（说明、 |
| it-IT | Italian (Italy) | NUDT15, interpretazione dell'attività metabolica del prodotto del gene Synonyms: Interpretazione dell''attività metabolica del prodotto del gene NUDT15 |
| es-ES | Spanish (Spain) | Interpretación de la actividad metabólica del producto del gen NUDT15 |
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