Version 2.77

Description

The mobilized colistin resistance genes (mcr-1 to mcr-5, and variants) are located on a plasmid within bacterial cells and affect the ability of antibiotics, including polymyxins and colistin, to bind to the bacteria. The mode of action of the antibiotics is to bind to the outer membrane of the phosphate group of lipid A lipopolysaccharide and to intercalate into the inner membrane forming pores that result in bacterial lysis. The polymyxins & colistin are the last line of defense used to treat multidrug resistant gram-negative bacteria so the emergence of the mcr genes in Enterobacteriaceae, including Klebsiella pneumoniae, is onerous and challenging to public health. PMID: 27893854 PMID: 29439754 Source: Regenstrief LOINC

Basic Part Properties

Part Display Name
Bacterial colistin resistance mcr-2 gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2019-10-06
Construct for LOINC Short Name
Colistin res mcr-2

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP411874-3

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 细菌粘菌素耐药 mcr-2 基因
Synonyms: 细菌粘菌素(多粘菌素 E、抗敌素、粘杆菌素、肠杆菌素)耐药(抗性、耐性、耐药性、抗药、抗药性、耐受、耐药型) mcr-2 基因
it-IT Italian (Italy) Gene mrc-2 di resistenza batterica alla colistina
nl-NL Dutch (Netherlands) bacteriële colistineresistentie mcr-2-gen
es-ES Spanish (Spain) Gen mcr-2 de resistencia baceriana a la colistina