LP417651-9
HLA-A & B & C (class I) Ab.IgG with prozone effect
Active
Descriptions
HLA antibodies showing the prozone effect represent antibody specificities against HLA antigens that were not apparent in undiluted patient specimen, but became apparent after dilution. This so called prozone effect has been attributed to a number of putative mechanisms, including complement factor, antibody agglutination or competing IgM. Prozone effect can often be reversed with serum dilution or treatment with heat, EDTA, or DTT. Source: Regenstrief LOINC
The major histocompatibility complex (MHC) class I (A, B, and C) and II (DP, DM, DOA, DOB, DQ, and DR) in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. The proteins encoded by some genes form antigens. HLA class I and II antigens are widely distributed on all nucleated cells and carried by platelets.
Antibodies specific to HLA class I and II antigens can be acquired through alloimmunization due to pregnancy, transfusion of blood products, or previous transplants. Alloimmunization can lead to production of antibodies in approximately one third of individuals. The presence of antibodies, specifically IgG, can affect the survival of transplant allografts or transfused platelets in sensitized individuals. Various testing methods are used to detect antibodies to HLA antigens.
Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- HLA-A and B and C (class I) IgG with prozone effect
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2020-02-06
- Construct for LOINC Short Name
- HLA class I Ab.IgG prozone
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | HLA-A 与 B 与 C (I 类) 抗体.IgG 伴前带效应 Synonyms: HLA-A 与 B 与 C (I 类) 抗体（Ab）.IgG 伴前带效应; |
| nl-NL | Dutch (Netherlands) | HLA A & B & C (klasse I) As.IgG met prozoneffect |
| it-IT | Italian (Italy) | HLA-A & B & C (classe I) Ab.IgG con effetto prozona Synonyms: HLA-Ae B e C (classe I) Ab.IgG con effetto prozona |
| es-ES | Spanish (Spain) | HLA-A , B , C (clase I) con efecto prozona por Ac IgG |
| pl-PL | Polish (Poland) | HLA-A & B & C (klasa I) Ab.IgG z efektem prozony Synonyms: Przeciwciała IgG do HLA-A, B i C (klasa I) ze efektem prozony |
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