LP420082-2
TFE3 gene rearrangements
Active
Description
The TFE3 (transcription factor binding to IGHM enhancer 3) gene [HGNC Gene ID: 1752] is located on chromosome X at position p11.23. This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013][NCBI Gene ID: 7030] Source: NCBI PubMed
Basic Part Properties
- Part Display Name
- TFE3 gene rearrangements
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2020-08-17
- Construct for LOINC Short Name
- TFE3 rearrange
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| it-IT | Italian (Italy) | TFE3, gene riarrangiamenti |
| nl-NL | Dutch (Netherlands) | TFE3-genherschikking Synonyms: TFE3-gentranslocaties |
| es-ES | Spanish (Spain) | Reordenamientos del gen TFE3 |
| zh-CN | Chinese (China) | TFE3 基因重排 Synonyms: TFE3 基因重排（重组） |
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