Version 2.78

Description

Dedicator of cytokinesis 8 (DOCK8) protein plays a role in regulating the cellular cytoskeleton, particularly microfilaments. DOCK8 is important in immunity by contributing to cellular migration, cytotoxicity, antibody production, and immunological memory. Deficiency of DOCK8 causes an immunodeficiency that presents in childhood with features including recurrent sinopulmonary infections, cutaneous viral infection, Staphylococcus aureus skin infections, cancer, and atopic disease (due to hyperimmunoglobulin E). NK cells (CD45+CD14-CD3-CD56+), T cells (CD3+CD14-CD45+), B cells (CD3-CD14-CD19+CD45+), and monocytes (CD45+CD14+) are all expected to express the DOCK8 protein. Therefore, assessment of DOCK8 expression on immune cells facilitates the diagnosis of DOCK8 deficiency. PMID: 28625885 Source: Regenstrief LOINC

Basic Part Properties

Part Name
DOCK8 expression panel
Part Display Name
DOCK8 expression panel
Part Type
Component (Describes the core component or analyte measured)
Created On
2020-08-17
Construct for LOINC Short Name
DOCK8 Expr Pnl

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP420097-0

Language Variants Get Info

Tag Language Translation
it-IT Italian (Italy) Espressione di DOCK8, panel
es-ES Spanish (Spain) Panel de expresión DOCK8
zh-CN Chinese (China) DOCK8 表达组套
Synonyms: DOCK8（胞质分裂作用因子 8）表达（基因表达）组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）;胞质分裂作用因子8;Dedicator of Cytokinesis number 8;DOCK8
nl-NL Dutch (Netherlands) DOCK8-expressie panel