LP420673-8
ABL1 & ABL2 & PDGFRB gene rearrangements
Active
Description
Rearrangements or fusions involving ABL-class genes, including ABL1, ABL2 and PDGFRB, are associated with BCR-ABL1-like B-lymphoblastic leukemia/lymphoma (BCR-ABL1-like B-ALL), also known as Philadelphia-like (Ph-like) ALL. Ph-like ALL is characterized as a neoplasm of B lymphoblasts having gene expression similar to BCR-ABL1+ B-ALL cases but lacking the BCR-ABL1 translocation. Several methods are used to diagnose Ph-like ALL, including gene expression profiling (the "gold standard"), conventional karyotyping, fluorescence in situ hybridization (FISH), reverse-transcription polymerase chain reaction (RT-PCR), and various sequencing techniques. For positive FISH studies, additional fusion probe or RT-PCR testing is needed to identify translocation partners. Patients with Ph-like ALL have a poor prognosis but respond well to targeted therapy when the genetic cause is identified. Treatment options include tyrosine kinase inhibitors (TKIs) and chemotherapy. PMID: 29696694 PMID: 25682595 Source: Regenstrief LOINC
Basic Part Properties
- Part Display Name
- ABL1 and ABL2 and PDGFRB gene rearrangements
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2020-10-24
- Construct for LOINC Short Name
- ABL1 + ABL2 + PDGFRB rearrange
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| it-IT | Italian (Italy) | ABL1 & ABL2 & PDGFRB, riarrangiamenti dei geni Synonyms: Riarrangiamenti dei geni ABL1 e ABL2 e PDGFRB |
| es-ES | Spanish (Spain) | Reordenamientos de los genes ABL1 y ABL2 y PDGFRB |
| zh-CN | Chinese (China) | ABL1 & ABL2 & PDGFRB 基因重排 Synonyms: ABL1 & ABL2 & PDGFRB 基因重排（重组） |
| nl-NL | Dutch (Netherlands) | ABL1 & ALB2 & PDGFRB genherschikking Synonyms: ABL1 & ALB2 & PDGFRB gentranslocaties |
LOINC Copyright
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