Version 2.80

Descriptions

A procollagen peptide contains an additional peptide sequence, termed the propeptide, at its amino and carboxy terminal ends. Collagen types I, II, III, IV and V are synthesized as precursor molecules called procollagens. Propeptides facilitate the winding of procollagen molecules into a triple-helix conformation within the endoplasmic reticulum. These propeptides are then cleaved from the collagen triple helix molecule during its secretion, after which the collagens polymerize into extracellular collagen fibrils. Thus, the amount of free propeptides directly correlates with collagen molecule synthesis. Procollagen Type I C-peptide (PIP) has also been extensively referenced in correlation studies between collagen levels and certain health disorders such as bone disease, alcoholic liver disease, liver cirrhosis and cirrhosis (Borrmann type IV) adenocarcinoma of the stomach. Source: Regenstrief Help

Procollagen type I N-terminal propeptide is considered a sensitive marker of bone formation and it is particularly useful for monitoring treatment for osteoporosis in postmenopausal women, and Paget's disease of the bone. Type I collagen constitutes 90% of bone proteins and is synthesized as type I procollagen. During the extracellular processing of type I procollagen, the amino terminal [N-terminal propeptide of type I collagen] and carboxy terminal propeptide are separated. These propeptides circulate in the bloodstream, where they are markers of bone formation. Procollagen type I N-terminal propeptide circulates as different forms, including the intact authentic trimeric procollagen type I N-terminal propeptide, a monomer, and several fragments. PMID: 17998267 Source: Regenstrief LOINC , PMID: 17998267

Basic Part Properties

Part Name
Procollagen type I.N-terminal propeptide
Part Display Name
Procollagen type I.N-terminal propeptide
Part Type
Component (Describes the core component or analyte measured)
Created On
2006-10-26
Construct for LOINC Short Name
PINP

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP57671-7

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 前胶原肽.I 型 N-末端
Synonyms: 1 型前胶原肽 N-末端;1 型前胶原肽氨基末端;I 型前胶原肽 N-末端;I 型前胶原肽氨基末端;P1NP;PINP;前胶原肽.1 型 氨基末端;前胶原肽.1 型 N-末端;前胶原肽.I 型 氨基末端
es-ES Spanish (Spain) Péptido N-terminal del procolágeno tipo I
it-IT Italian (Italy) Procollagene, peptide.tipo 1 N-Terminale
Synonyms: Peptide del procollagene di tipo 1 N-Terminale
et-EE Estonian (Estonia) I tüüpi prokollageeni N-fragment
tr-TR Turkish (Turkey) Prokollajen peptid.tip 1 N-Terminal
ru-RU Russian (Russian Federation) Проколлаген пептид.тип 1 N-Терминаль
fr-BE French (Belgium) Peptide du procollagène.type 1 N-terminal
Synonyms: PNPP-1
fr-CA French (Canada) Procollagène type I.N-terminal propeptide
nl-NL Dutch (Netherlands) procollageenpeptide.type 1 N-terminaal
el-GR Greek (Greece) Προκολλαγόνο τύπου I.N-τερματικό προπεπτίδιο
Synonyms: Προκολλαγόνο τύπου I.N-τερματικό προπεπτίδιο