Description

The minimum lethal concentration (MLC) is the most common procedure used to determine the minimum bactericidal concentration (MBC) or the minimum fungicidal concentration (MFC). A precise aliquot of culture from the MIC wells or tubes that exhibited no growth are sub-cultured onto a non-selective agar plate and allowed to incubate for 24 hours. The number of colony-forming units per milliliter (CFU/mL) is determined. The MBC is defined as the lowest concentration of antibiotic that kills 99.9% of the final inoculum after a 24 hour incubation an in accordance with the standardized conditions stated in document M26-A. The MFC is defined as the lowest concentration of drug that kills 98-99.9% when compared to the initial inoculum (the sample in the clear wells or tubes).[Balouiri, Mounyr., Sadiki, Moulay., Ibnsouda, Saad Koraichi. "Methods for in vitro evaluating antimicrobial activity: A review". Journal of Pharmaceutical Analysis. Volume 6 (2016): Pages 71-79.] Source: Regenstrief LOINC

Basic Part Properties

Part Name
MLC
Part Display Name
Minimum lethal concentration (MLC)
Part Type
Method (Describes the method by which the test was performed)
Created On
2000-05-03
Construct for LOINC Short Name
MLC

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP6402-4

Language Variants Get Info

TagLanguageTranslation
zh-CNChinese (China)最小致死浓度法
Synonyms: 最低杀菌浓度;最低杀菌浓度(Minimum bactericidal concentration,MBC);最低杀菌浓度法;最低致死浓度;最低致死浓度(Minimum Lethal Concentration,MLC);最低致死浓度法;最小杀菌浓度;最小杀菌浓度(Minimum bactericidal concentration,MBC);最小杀菌浓度法;最小致死浓度;最小致死浓度(Minimum Lethal Concentration,MLC)
fr-CAFrench (Canada)CLM
et-EEEstonian (Estonia)MLK
Synonyms: Minimaalne letaalne kontsentratsioon
es-ESSpanish (Spain)Concentración mínima bactericida (CMB)
it-ITItalian (Italy)MLC
Synonyms: Concentrazione minima letale (MLC)
tr-TRTurkish (Turkey)MLC
nl-NLDutch (Netherlands)minimaal dodelijke concentratie
Synonyms: MLC
fr-BEFrench (Belgium)CLM
fr-FRFrench (France)Concentration minimale létale
pl-PLPolish (Poland)minimalne stężenie śmiertelne, MLC
el-GRGreek (Greece)MLC
Synonyms: MLC