LP90871-2

Monofluoroacetate

Active

Description

Fluoroacetate is similar to acetate, which has a pivotal role in cellular metabolism. Fluoroacetate disrupts the citric acid cycle (also known as the Krebs cycle) by combining with coenzyme A to form fluoroacetyl CoA, which reacts with citrate synthase to produce fluorocitrate. A metabolite of fluorocitrate binds very tightly to aconitase, thereby halting the citric acid cycle. This inhibition results in an accumulation of citrate in the blood which deprives cells of energy. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Fluoroacetic acid

Basic Part Properties

Part Name

Monofluoroacetate

Part Display Name

Monofluoroacetate

Part Type

Component (Describes the core component or analyte measured)

Created On

2009-01-26

Construct for LOINC Short Name

Monofluoroacetate

Related Codes

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