LP94227-3
Zygosity
Active
Description
Polymorphic DNA markers are used to determine if twins (triples, etc.) are monozygotic (identical) or dizygotic (fraternal). In some cases, labs may require DNA from the parents to ensure markers are informative and provide the most accurate results. Genotypes derived from the analysis of the markers are compared between the siblings (and parents). Any differences indicate dizygosity. If siblings share the same genotypes, they are considered identical.
Zygosity testing is performed for several reasons, including determining genetic risk for an individual whose sibling is affected with a genetic disorder for which a specific genetic test is uninformative or not available, assessing risks prenatally when one fetus of multiples is known to be affected by a specific disorder, performing organ or bone marrow transplantation compatibility testing, evaluating twin-twin transfusion syndrome during pregnancy, and for general familial or parental interest.
Source: Regenstrief LOINC
Reference Information
| Type | Source | Reference |
|---|---|---|
| Article | NCBI PubMed | Neitzel H, et al. Routine applications of DNA fingerprinting with the oligonucleotide probe (CAC)5/(GTG)5. Clinical Genetics.1991 Feb;39(2):97-103. PMID 1849805 |
Basic Part Properties
- Part Name
- Zygosity
- Part Display Name
- Zygosity
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2009-03-13
- Construct for LOINC Short Name
- Zygosity
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 接合性 Synonyms: 卵型; |
| es-ES | Spanish (Spain) | Zigosidad de gemelos |
| it-IT | Italian (Italy) | Gemelli, zigosità Synonyms: DNA di zigosità di gemelli |
| tr-TR | Turkish (Turkey) | ZigositeDNA |
| ru-RU | Russian (Russian Federation) | Зиготность Synonyms: Зиготность ДНК |
| nl-NL | Dutch (Netherlands) | zygositeit |
| fr-FR | French (France) | Zygosité |
| pl-PL | Polish (Poland) | Zygotyczność |
| el-GR | Greek (Greece) | Ζυγωτία Synonyms: Ζυγωτία |
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://