LP94560-7
Coagulation ecarin induced
Active
Description
Ecarin clotting time (ECT) is a laboratory test used to monitor anticoagulation during treatment with hirudin, an anticoagulant medication which was originally isolated from leech saliva. Ecarin, the primary reagent in this assay, is derived from the venom of the saw-scaled viper, Echis carinatus.
In the clinical assay, a known quantity of ecarin is added to the plasma of a patient treated with hirudin. Ecarin activates prothrombin through a specific proteolytic cleavage, which produces meizothrombin, a prothrombin-thrombin intermediate which retains the full molecular weight of prothrombin, but possesses a low level of procoagulant enzymatic activity. Crucially, this activity is inhibited by hirudin and other direct thrombin inhibitors, but not by heparin. The ECT is also unaffected by prior treatment with coumadin or the presence of phospholipid-dependent anticoagulants, such as lupus anticoagulant. Thus, the ECT is prolonged in a specific and linear fashion with increasing concentrations of hirudin.
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Source: Wikipedia
, Ecarin clotting time
Basic Part Properties
- Part Name
- Coagulation ecarin induced
- Part Display Name
- Coagulation ecarin induced
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2009-04-16
- Construct for LOINC Short Name
- ECT
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Retracción del coágulo inducida |
| it-IT | Italian (Italy) | Coagulazione ecarin indotta |
| zh-CN | Chinese (China) | 锯鳞蝰蛇毒诱导型凝血过程 Synonyms: ecarin |
| tr-TR | Turkish (Turkey) | Koagülasyon ekarin uyarılmış |
| ru-RU | Russian (Russian Federation) | Коагуляция экарин индуцированная |
| fr-BE | French (Belgium) | Temps de céphaline induite par écarine |
| fr-CA | French (Canada) | Temps de céphaline induite par écarine |
| nl-NL | Dutch (Netherlands) | stolling ecarinegeïnduceerd Synonyms: stolling ecarine geinduceerd |
| pl-PL | Polish (Poland) | ECT |
| el-GR | Greek (Greece) | Πήξη επαγόμενη από εκαρίνη Synonyms: Πήξη επαγόμενη από εκαρίνη |
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