Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. PMID: 21214559 Source: Regenstrief LOINC, PMID: 2121455
Basic Part Properties
- Part Display Name
- Ganglioside GT1b
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- Construct for LOINC Short Name
- GT1b Ganlg
LOINC Terminology Service (API) using
HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
Language Variants Get Info
|zh-CN||Chinese (China)||神经节苷脂 GT1b
|fr-CA||French (Canada)||Ganglioside GT1b|
|es-ES||Spanish (Spain)||Gangliosido GT1b|
|it-IT||Italian (Italy)||Ganglioside GT1b|
|tr-TR||Turkish (Turkey)||Gangliozid GT1b|
|ru-RU||Russian (Russian Federation)||Ганглиозид GT1b|
|nl-NL||Dutch (Netherlands)||ganglioside GT1b|
|fr-BE||French (Belgium)||Ganglioside GT1b|
Copyright © 2023 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright