Molecular test mapping for alpha/beta globin genotype

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This topic contains 2 replies, has 2 voices, and was last updated by  Fong Ka Yin 5 years, 7 months ago.

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    Fong Ka Yin

    Dear all,

    Anyone experiened LOINC mapping with alpha/beta/zeta globin genotyping?

    I am wondering what is the analyte.

    For example, the local test description is ” Alpha globin genotype 1:” and “Beta globin genotype 1:” with free text results.

    The descripiton is for the detection of genotype; however, no related LOINC code for HBA1 genotype.

    Can I use HBA1 gene as the analyte?

    Any advice?




    Hi Barry,

    We have a few codes for HBA1 and HBA2 gene mutation analysis that may work. They can be viewed here:*. If the lab is testing for a specific mutation or deletion, we recommend mapping to the corresponding LOINC code (e.g, LOINC 55247-1).

    Currently we do not have codes for HBZ gene testing. We welcome a formal submission sent to For more information, see

    The current model for how LOINC names molecular genetic tests is described in the User’s guide, Section 3.9:

    Hope this helps!

    Jami Deckard, MS
    LOINC Content Developer


    Fong Ka Yin

    Hi Jami,

    Thank you for your suggestions. Basically the results might show mutation (e.g. -3.7, -4.2) or genotype (e.g. aa) if no mutation is found. Would that be appropriate if we use [21687-9 ] HBA1 gene mutations found [Identifier] in Blood or Tissue by Molecular genetics method Nominal?

    Beside, we found that [21688-7] is same as [21687-9] except the analyte is “HBA1 gene mutation tested for“. Should we
    consider [21688-7] for this case? what does “tested for” means?


    Barry FONG

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