LOINC
Version 2.73

100344-1Influenza virus A RNA [Presence] in Saliva (oral fluid) by NAA with probe detectionActive

Term Description

This is a real-time RT-PCR for qualitative detection Influenza A virus RNA in saliva specimens. The test could be a single assay or part of a multiplex panel to detect Influenza A virus and other pathogens. The test could target a single Influenza A virus gene (e.g., the matrix protein gene) or it could target multiple genes.
Source: Regenstrief LOINC

Part Descriptions

LP14239-5   Influenza virus A
Influenza viruses, from the family Orthomyxoviridae, are enveloped negative-strand RNA viruses with segmented genomes containing seven to eight gene segments. Of the five genera in the family, only influenza A virus (IAV), influenza B and C are medically relevant to humans. Aquatic birds harboring avian IAV are the likely natural reservoir for all known IAV subtypes and are probably the original source of all human pandemic IAV strains. IAV maintained in wild birds have been associated with stable host switch events to novel hosts, including most often to domestic poultry but also to horses, swine, toothed whales and humans. The influenza virus life cycle begins with the binding of viral HA to host cell receptors. Endocytosis and HA-mediated fusion of the viral and cellular membranes occurs. Viral ribonucleoprotein complexes are released into the cytoplasm, travel to the nucleus, then are replicated and transcribed by the viral polymerase complex. The new viruses are formed and bud when the newly formed ribonucleicprotein complexes and structural proteins reach the plasma membrane. Further research is needed to better understand how IAVs switch hosts and the viral genetic changes that underlie human adaptation. IAV causes respiratory infections in humans ranging from asymptomatic to fatal. Pandemics are attributed to "novel" viruses which possess a viral hemagglutinin (HA) to which humans do not have immunity. [PMID:20542248] [PMID:25812763]
Influenza viruses A and B are single-stranded RNA enveloped viruses belonging to the Orthomyxoviridae family. The symptoms of infection of Influenza A and B include fever, cough, sore throat, rhinorrhea, nasal congestion, headache, myalgia and malaise. Some patients may experience gastrointestinal symptoms including watery diarrhea, vomiting and abdominal pain. The influenza viruses spread rapidly in enclosed spaces with a documented rate of infection of 70% following a common source of exposure. Infection occurs in the respiratory epithelium in both the upper and lower respiratory tract, and the virus can be found in many specimen types, including nasal aspirates, nasal or nasopharyngeal swabs, throat swabs, sputum and tracheal aspirates. When infection rates reach epidemic proportions, hospitalization of children and elderly patients rises as does the mortality rates of elderly patients.(Manual of Clinical Microbiology, 11th edition, James H. Jorgensen; Karen C. Carroll; Guido Funke; Michael A Pfaller; Marie Louise Landry; Sandra S. Richter; David W. Warnock) Source: Regenstrief LOINC

LP7565-7   Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin.[PMID:17268583] Source: Regenstrief LOINC

Fully-Specified Name

Component
Influenza virus A RNA
Property
PrThr
Time
Pt
System
Saliva
Scale
Ord
Method
Probe.amp.tar

Additional Names

Short Name
FLUAV RNA Sal Ql NAA+probe
Display Name
FLUAV RNA NAA+probe Ql (Sal)
Consumer Name Alpha
Influenza A (Flu A), Saliva

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.73
Last Updated
Version 2.73
Order vs. Observation
Both

Member of these Groups

LG32757-3 Influenza virus

Language Variants Get Info

zh-CNChinese (China)
流感病毒 A 型 RNA:存在情况或阈值:时间点:唾液:序数型:探针法.基因扩增.靶向
nl-NLDutch (Netherlands)
Influenzavirus A RNA:aanwezigheid:moment:speeksel:ordinaal:moleculaire techniek (PCR)
fr-BEFrench (Belgium)
Virus de l'influenza A ARN:PrThr:Temps ponctuel:Salivaire:Ordinal:Sonde avec amplification de la cible
fr-CAFrench (Canada)
Virus de l'influenza A , ARN:Présence-Seuil:Temps ponctuel:Salivaire:Ordinal:Sonde avec amplification de la cible
it-ITItalian (Italy)
Influenza A, virus RNA:PrThr:Pt:Saliva:Ord:Sonda.amp.tar
ru-RURussian (Russian Federation)
Грипп вирус А РНК:PrThr:ТчкВрм:Слюна:Пор:Проба.усил.миш
es-ESSpanish (Spain)
Virus Influenza A RNA:PrThr:Punto temporal:Saliva:Ord:Sonda con amplificación dirigida
tr-TRTurkish (Turkey)
İnfluenza virüsü A RNA:MevcEşik:Zmlı:Tükürük:Srl:Prob.amf.hdf

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=100344-1