LOINC
Version 2.73

100857-2CD3+CD8+ (T8 suppressor) cells/100 cells in Blood mononuclear cellsTrial

Status Information

Status
Trial

Part Descriptions

LP17728-4   Cells.CD3+CD8+
HIV infection decreases the number of CD3+ CD4+ lymphocytes (also called CD4 T cells or T4 helper cells) while increasing (momentarily) the numbers of CD3+CD8+ lymphocytes (called CD8 T lymphocytes or cytotoxic T cells). Thus the ratio of CD4/CD8 lymphocytes is decreased. These counts are used for prognostic purposes and to guide in the retroviral therapy. CDC has emphasized since 1997 that the number of CD3+ lymphocytes is necessary in addition to the number of CD4+ cells to reliably identify the T4 helper cells and the number of CD8+ cells. Laboratory reports that include only CD4 or only CD8 in their nomenclature are most likely really measuring CD3+CD4+ cells and CD3+CD8+ cells, respectively. Source: Regenstrief Help

LP17728-4   Cells.CD3+CD8+
HIV infection decreases the number of CD4 T-cells, also called T4 helper cells, the ratio of CD4 to CD8 T-cells and the number of CD8+ T-cells. These counts are ordered frequently to guide decisions about anti-retroviral therapy. Laboratories usually report both percentage and absolute count. When you map CD4 and CD8 markers, be careful! Since at least 1997, CDC has required the detection of both CD3+ and CD4+ to identify T4 helper cells, because the CD3 marker is needed to identify T-cell . So, any tests that report T4 helper cells are really reporting cells that carry BOTH the CD3+ and the CD4+ markers. The measure name may be CD3+ CD4+ cells, CD4+ marker, T4 cells or even just CD4+ (a misnomer). Exactly analogous rules apply to CD8+. Measures that include only CD4 or only CD8 in their name are really measuring CD3+CD4+ cells or CD3+CD8+ cells, respectively and should be reported with the LOINC code that includes both of those markers. The panel named T cell subsets will usually contain both CD3 + CD4 and CD3 + CD8 counts. These names assume that one has already gated to lymphocytes only. Lymphocytes are identified by CD45 markers. So a CD45+CD3+CD4+ is a more complicated way to name CD3+C4+ cells and in the context of looking for CD4 helper T cells they are the same . The same applies to other flow cytometer measures that are looking only at lymphocytes (B-cells, NK cells, etc). Source: Regenstrief Help

LP17729-2   CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

Fully-Specified Name

Component
Cells.CD3+CD8+/100 cells
Property
NFr
Time
Pt
System
Bld MC
Scale
Qn
Method

Additional Names

Short Name
CD3+CD8+ Cells Bld MC-NFr
Display Name
CD3+CD8+ (T8 suppressor) cells/100 cells (Bld MC)
Consumer Name Alpha
CD3+CD8+ (T8 Suppressor) Cells per 100 cells, Blood

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.73
Last Updated
Version 2.73
Order vs. Observation
Both

Language Variants Get Info

zh-CNChinese (China)
细胞.CD3+CD8+/100 个细胞:计数型分数:时间点:全血单个核细胞:定量型:
nl-NLDutch (Netherlands)
cellen.CD3+CD8+/100 cellen:getalsfractie:moment:mononucleaire cellen in bloed:kwantitatief:
it-ITItalian (Italy)
Cellule.CD3+CD8+/100 cellule:NFr:Pt:Cellule mononucleate da sangue intero:Qn:
es-ESSpanish (Spain)
Células CD3+CD8+/100 células:Fracción numérica:Punto temporal:Celulas Mononucleares sanguíneas:Qn:
tr-TRTurkish (Turkey)
Hücreler.CD3+CD8+/100 hücre:SayFr:Zmlı:Kan MC:Kant:

Example Units

Unit Source
% Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=100857-2