101145-1

Ustekinumab [Mass/volume] in Serum or Plasma by Immunoassay --trough

Active

Part Descriptions

LP20176-1 trough
In medicine, a trough level is the lowest level that a medicine is present in the body. In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. It should be contrasted with a "peak level", which is the highest level of the medicine in the body, and the "average level", which is the mean level over time. It helps in therapeutic drug monitoring. It is widely used in clinical trials for newer medicines for its therapeutic effectiveness and safety. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Trough levels for therapeutic drug monitoring

LP250851-5 Ustekinumab
Ustekinumab (UST) is a human immunoglobulin G1κ (IgG1κ) that binds sub-unit p40 of interleukin-12 (IL-12) and interleukin-23 (IL-23). IL-12 and IL-23 are parts of the Th1 and Th17 inflammatory pathways, respectively, and are important in the development of psoriasis. Psoriasis has pathogenic similarities to psoriatic arthritis (PsA) which is an inflammatory disorder that is often unresponsive to tumor necrosis factor (TNF) inhibitor therapy. Also, many patients with PsA who initially respond well to TNF inhibitors eventually stop responding. UST is not a TNF inhibitor and offers patients with PsA an alternative treatment which has been proven to be effective and safe for short-term use. The safety for long-term use of UST still needs further study. PMID: 24101949 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Ustekinumab^trough:MCnc:Pt:Ser/Plas:Qn:IA
Long Common Name: Ustekinumab [Mass/volume] in Serum or Plasma by Immunoassay --trough
Short Name: Ustekinumab Trough SerPl IA-mCnc
Display Name: Ustekinumab trough IA [Mass/Vol]
Consumer Name Alpha Get Info: Ustekinumab trough, Blood

Part Model Get Info

Component
Ustekinumab^trough
LP434091-7
- Analyte
  Ustekinumab
  LP250851-5
  - Component Numerator
    Ustekinumab
    LP250851-5
    - Component Numerator Core
      Ustekinumab
      LP250851-5
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  trough
  LP20176-1
- Adjustment
  NULL
- Count
  NULL
Property
MCnc
LP6827-2
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser/Plas
LP7576-4
- System Core
  Ser/Plas
  LP7576-4
- Super System
  NULL
Scale
Qn
LP7753-9
Method
IA
LP217197-5

Basic Attributes

Class: DRUG/TOX
Type: Laboratory
First Released: Version 2.74
Last Updated: Version 2.75 (MIN)
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
101144-4	Ustekinumab and Ustekinumab Ab panel - Serum or Plasma

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Ustekinumab^Údolní koncentrace:Hmotnostní koncentrace:Časový bod:Sérum/plazma:Kvantitativní:Imunoanalýza
el-GR	Greek (Greece)	Ουστεκινουμάμπη^ελάχιστα επίπεδα:MCnc:Pt:Ορός/Πλάσμα:Qn:IA Synonyms: DRUG/TOX IA MCnc Pt Qn ελάχιστα επίπεδα Ορός Ορός/Πλάσμα Ουστεκινουμάμπη Πλάσμα
es-ES	Spanish (Spain)	Ustekinumab^Valle monitorización terapéutica de fármacos:Concentración de masa:Punto temporal:Suero o Plasma:Qn:IA Synonyms: Cuantitativo
fr-FR	French (France)	Ustekinumab^taux résiduel:Masse/Volume:Ponctuel:Sérum/Plasma:Numérique:Immunoanalyse
it-IT	Italian (Italy)	Ustekinumab^valore minimo:MCnc:Pt:Siero/Plasma:Qn:IA Synonyms: Concentrazione di Massa Immunoassay Livelli farmacologici e tossicologia Plasma Punto nel tempo (episodio) Siero Siero o Plasma valore minimo TDM
nl-NL	Dutch (Netherlands)	ustekinumab^dalspiegel:massa/volume:moment:serum of plasma:kwantitatief:immunoassay Synonyms: IA
zh-CN	Chinese (China)	优特克单抗^波谷:质量浓度:时间点:血清/血浆:定量型:免疫测定法 Synonyms: 一剂药物的初始剂量;初始剂量;剂量药物的初始剂量;前剂量;曲线上的最小值;最低点;本底剂量;治疗药物监测 - 波谷;预剂量优特克单克隆抗体;优特克;Ustekinumab 单抗;优斯它单抗;优特克诺免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验可用数量表示的;定量性;数值型;数量型;连续数值型标尺时刻;随机;随意;瞬间毒品毒品类水平;浓度;质量浓度(单位体积) 药品类药物药物/毒理学;药物/毒理学试验;药物毒理学试验;药物毒理学试验类药物类血清或血浆

Example Units

Unit	Source
ug/mL	Example UCUM Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=101145-1

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.