101662-5
Abnormal Prion Protein [Presence] in Cerebral spinal fluid by RT-QuIC
Active
Term Description
Detection of pathologic prions in cerebrospinal fluid (CSF). The test uses recombinant prion protein (PrP) as a reagent substrate and patient CSF in a real-time quaking-induced conversion (RT-QuIC) assay. If pathologic prions are present in the patient's CSF, they propagate misfolding of the reagent PrP to form amyloid, which is detected using a fluorescent indicator. RT-QuIC has been adopted in clinical practice due to the sensitivity, specificity, and use of CSF (not a brain biopsy) for testing. The reported sensitivity of RT-QuIC in detecting CJD is >90%, and the specificity approaches 100%.
Source: Regenstrief LOINC
Part Descriptions
LP35078-2 Prion protein.abnormal
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia, Transmissible spongiform encephalopathy
LP435248-2 RT-QuIC
Real-time quaking-induced conversion (RT-QuIC) a technique to detect small amounts of PrPSc.. RT-QuIC test manipulates the ability of PrPSc to induce PrPC to misfold in a cyclical fashion to form aggregates of PrPSc fibrils, in real time by binding to a fluorescent dye, namely thioflavin T.
Source: LOINC
Fully-Specified Name
- Component
- Prion protein.abnormal
- Property
- PrThr
- Time
- Pt
- System
- CSF
- Scale
- Ord
- Method
- RT-QuIC
Additional Names
- Short Name
- Abn Prion Prot CSF Ql RT-QuIC
- Display Name
- Abnormal Prion Protein RT-QuIC Ql (CSF)
- Consumer Name Alpha Get Info
- Abnormal prion protein, Spinal fluid
Example Answer List: LL2038-9
Source: Quest Diagnostics Inc.| Answer | Code | Score | Answer ID |
|---|---|---|---|
| PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) | LA6576-8 | ||
| NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) | LA6577-6 | ||
| IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value) | LA11884-6 |
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.75
- Last Updated
- Version 2.75
- Order vs. Observation
- Both
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 104134-2 | Dementia evaluation panel - Cerebral spinal fluid |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Proteína priónica anormal: Synonyms: Ensayo de conversión de proteína priónica inducida por agitación en tiempo real |
| fr-FR | French (France) | Protéine prion anormale: |
| it-IT | Italian (Italy) | Proteina prionica.anormale: Synonyms: Chimica Liquido cerebrospinale Presenza o Soglia Proteina Prionica Anormale Punto nel tempo (episodio) Real Time Quaking Induced Conversion |
| nl-NL | Dutch (Netherlands) | prioneiwit.abnormaal: Synonyms: real-time quaking-induced conversion |
| zh-CN | Chinese (China) | 朊病毒蛋白.异常: Synonyms: BSE; |
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