Version 2.78

Description

Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Transmissible spongiform encephalopathy

Basic Part Properties

Part Display Name
Abnormal Prion Protein
Part Type
Component (Describes the core component or analyte measured)
Created On
2005-02-15
Construct for LOINC Short Name
Abn Prion Prot

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP35078-2

Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 朊病毒蛋白.异常
Synonyms: BSE;Scrapie;亲染子蛋白.异常;异常亲染子蛋白;异常感染性蛋白质;异常朊病毒蛋白;异常蛋白感染素;感染性蛋白质.异常;牛海绵状脑病;牛海绵状脑病（Bovine spongiform encephalopathy，BSE）;疯牛病;羊痒病;羊瘙痒病;羊瘙痒病（Scrapie）;蛋白感染素.异常
fr-CA French (Canada) Protéines prion.anormales
es-ES Spanish (Spain) Proteína priónica anormal
it-IT Italian (Italy) Proteina prionica.anormale
Synonyms: Proteina Prionica Anormale
tr-TR Turkish (Turkey) Prion protein.anormal
ru-RU Russian (Russian Federation) Прионный протеин.аномальный
Synonyms: Прионный белок.аномальный
nl-NL Dutch (Netherlands) prioneiwit.abnormaal
fr-BE French (Belgium) Protéines prion.anormales