Version 2.78

Part Description

LP15684-1   Kynurenate
Kynurenic acid (KYNA) is a product of the normal metabolism of amino acid L-tryptophan. It has been shown that kynurenic acid possesses neuroactive activity. It acts as an antiexcitotoxic and anticonvulsant, most likely through acting as an antagonist at excitatory amino acid receptors. Because of this activity, it may influence important neurophysiologic and neuropathologic processes. As a result, kynurenic acid has been considered for use in therapy in certain neurobiological disorders. Conversely, increased levels of kynurenic acid have also been linked to certain pathological conditions.

High levels of kynurenic acid have been identified in patients suffering from tick-borne encephalitis, schizophrenia and HIV-related illnesses. In all these situations increased levels were associated with confusion and psychotic symptoms. Kynurenic acid acts in the brain as a glycine-site NMDAr antagonist, key in glutamatergic neurotransmission system, which is thought to be involved in the pathophysiology and pathogenesis of schizophrenia.

A kynurenic acid hypothesis of schizophrenia has been proposed in 2007, based on its action on midbrain dopamine activity and NMDArs, thus linking dopamine hypothesis of schizophrenia with the glutamate hypothesis of the disease.

High levels of kynurenic acid have been identified in human urine in certain metabolic disorders, such as marked pyridoxine deficiency and deficiency/absence of kynureninase. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Kynurenic acid

Fully-Specified Name

Component
Kynurenate
Property
MRto
Time
Pt
System
Urine
Scale
Qn
Method

Additional Names

Long Common Name
Kynurenate [Mass Ratio] in Urine
Short Name
KYN Ur
Display Name
Kynurenate (U) [Mass ratio]
Consumer Name Alpha Get Info
Kynurenate, Urine

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.75
Last Updated
Version 2.75
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Quinurenato:Relacion de Masa:Punto temporal:Orina:Qn:
Synonyms: Cuantitativo
fr-BE French (Belgium) Kynurénate:Ratio de masse:Temps ponctuel:Urine:Quantitatif:
Synonyms: Rapport de masse
fr-CA French (Canada) Kynurénate:Ratio de masse:Temps ponctuel:Urine:Quantitatif:
fr-FR French (France) Cynurénate:Masse ratio:Ponctuel:Urine:Numérique:
it-IT Italian (Italy) Chinurenato:MRto:Pt:Urine:Qn:
Synonyms: Chimica Punto nel tempo (episodio) Rapporto di Massa
nl-NL Dutch (Netherlands) kynurenaat:massaverhouding:moment:urine:kwantitatief:
ru-RU Russian (Russian Federation) Кинуренат:МассОтн:ТчкВрм:Моча:Колич:
Synonyms: Количественный Масс отношение Точка во времени;Момент
tr-TR Turkish (Turkey) Kinirenat:KütlOr:Zmlı:İdrar:Kant:
zh-CN Chinese (China) 犬尿氨酸:质量比率:时间点:尿液:定量型:
Synonyms: KYN;KYNA;犬尿氨酸（Kynurenic acid，KYNA） 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 尿;小便;下泉 时刻;随机;随意;瞬间 来自于同一体系的两种分析物的质量之比;质量比

Example Units

Unit Source
ug/g{creat} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=101993-4