Version 2.78

Term Description

Transmissible spongiform encephalopathies (TSEs or prion diseases) are a rare group of invariably fatal neurodegenerative disorders that affect humans and other mammals. TSEs are protein misfolding diseases that involve the accumulation of an abnormally aggregated form of the normal host prion protein (PrP). They are unique among protein misfolding disorders in that they are transmissible and have different strains of infectious agents that are associated with unique phenotypes in vivo. https://pubmed.ncbi.nlm.nih.gov/19157856/#:~:text=Abstract,host%20prion%20protein%20(PrP).
Source: Regenstrief LOINC

Part Descriptions

LP35078-2   Prion protein.abnormal
Transmissible spongiform encephalopathies (TSEs), also known as prion diseases, are a group of progressive conditions (encephalopathies) that affect the brain and nervous system of many animals, including humans. According to the most widespread hypothesis they are transmitted by abnormal prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and a myriad of tiny holes appear in the cortex causing it to appear like a sponge (hence spongiform) when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen over time. Most TSEs are sporadic and occur in animals. Prion diseases of animals in include classical bovine spongiform encephalopathy (BSE) (C-type), atypical (H or L-type) BSE, Scrapie, atypical scrapie, Nor98, and chronic wasting disease (CWE). H-type and L-type BSE were named based on abnormal prion bands migrating to a higher (H) or lower (L) position on western blot analysis compared to the classical BSE (C-type) prion protein. Prion diseases of humans include classic Creutzfeldt-Jakob disease, new variant Creutzfeldt-Jakob disease (nvCJD, a human disorder related to Bovine spongiform encephalopathy), Gerstmann-Sträussler-Scheinker syndrome, fatal familial insomnia and kuru. These conditions form a spectrum of diseases with overlapping signs and symptoms. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Transmissible spongiform encephalopathy

LP435248-2   RT-QuIC
Real-time quaking-induced conversion (RT-QuIC) a technique to detect small amounts of PrPSc.. RT-QuIC test manipulates the ability of PrPSc to induce PrPC to misfold in a cyclical fashion to form aggregates of PrPSc fibrils, in real time by binding to a fluorescent dye, namely thioflavin T. Source: LOINC

Fully-Specified Name

Component
Prion protein.abnormal
Property
Imp
Time
Pt
System
CSF
Scale
Doc
Method
RT-QuIC

Additional Names

Short Name
Abn Prion Prot CSF Doc RT-QuIC-Imp
Display Name
Abnormal Prion Protein RT-QuIC Doc (CSF) [Interp]
Consumer Name Alpha Get Info
Abnormal prion protein, Spinal fluid

Basic Attributes

Class
MICRO
Type
Laboratory
First Released
Version 2.75
Last Updated
Version 2.75
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Proteína priónica anormal:Impresión/interpretación del estudio:Punto temporal:Líquido Cefalorraquideo:Doc:RT-QUIC
Synonyms: Ensayo de conversión de proteína priónica inducida por agitación en tiempo real
fr-FR French (France) Protéine prion anormale:Interprétation:Ponctuel:Liquide céphalorachidien:Document:RT-QuIC
it-IT Italian (Italy) Proteina prionica.anormale:Imp:Pt:LCS:Doc:RT-QuIC
Synonyms: Impressione/interpretazione di studio Liquido cerebrospinale Microbiologia Proteina Prionica Anormale Punto nel tempo (episodio) Real Time Quaking Induced Conversion
nl-NL Dutch (Netherlands) prioneiwit.abnormaal:interpretatie:moment:liquor cerebrospinalis:document:RT-QulC
Synonyms: real-time quaking-induced conversion
zh-CN Chinese (China) 朊病毒蛋白.异常:印象:时间点:脑脊液:文档型:RT-QuIC
Synonyms: BSE;Scrapie;亲染子蛋白.异常;异常亲染子蛋白;异常感染性蛋白质;异常朊病毒蛋白;异常蛋白感染素;感染性蛋白质.异常;牛海绵状脑病;牛海绵状脑病（Bovine spongiform encephalopathy，BSE）;疯牛病;羊痒病;羊瘙痒病;羊瘙痒病（Scrapie）;蛋白感染素.异常 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 PR;Prot;成分 - 化学 - 蛋白质类;蛋白;朊;蛋白质类;蛋白质类物质 不平常的 不正常的 临床文档型;临床文档;文档;文书;医疗文书;临床医疗文书 亲染子蛋白 印象是一种诊断陈述，始终是对其他某种观察指标的解释或抽象（一系列检验项目结果、一幅图像或者整个某位病人），而且几乎总是由某位专业人员产生。;检查印象;检查印象/解释;检查的印象/解释;检查解释;解释;阐释 反常的 实时震荡诱导转化 异常的 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体） 感染性蛋白质 时刻;随机;随意;瞬间 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 蛋白感染素 非一般的 非惯例的

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=102036-1