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LP16800-2   Aluminum
Aluminium (Al) is a metal which is distributed throughout our environment. It has been used since approximately 1887. Al is widely used in multiple industries and consumer products. It has no known function in biology. Al usually enters the human body via cooking utensils or pharmicological agents such as antacids (Al (OH)3 )and antiperspirants. Aluminum salts are remarkably nontoxic, aluminum sulfate having an LD50 of 6207 mg/kg (oral, mouse), which corresponds to 500 grams for an 80 kg (180 lb) person. Aluminum is excreted by filtration by the glomeruli of the kidney. Patients in renal failure lose the ability to clear aluminum, and aluminum toxicity may be a concern. Aluminum accumulates in the blood and binds to proteins such as albumin, and then distributed throughout the body.Because aluminum competes with calcium for absorption, increased amounts of dietary aluminum may contribute to the reduced skeletal mineralization (osteopenia) observed in preterm infants and infants with growth retardation. In very high doses, aluminum is associated with altered function of the blood-brain barrier. A small percentage of people are allergic to aluminum and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminum. In those without allergies, aluminum is not as toxic as heavy metals, but there is evidence of some toxicity if consumed in amounts greater than 40 mg/day per kg of body mass. Aluminum is classified as a non-carcinogen by the US Department of Health and Human Services. In case of suspected sudden intake of a large amount of aluminum, deferoxamine mesylate may be given to help eliminate it from the body by chelation. (Tietz: Clinical Guide to Laboratory Tests, Fourth Edition)
The mechanism of how the neurotoxicity of AI occurs is still unclear. Evidence suggests that oxidative stress and inflammatory processes lead to cell death. As a neurotoxin, Al is considered has been linked to the development of neurodegenerative diseases, including Alzheimer's disease (AD), dementia, Amyotrophic Lateral Sclerosis (ALS) Parkinsonism and even Gulf war syndrome. PMID: 27479193 (for human medicine)

Veterinary Medicine:
In veterinary medicine, the impact of aluminum toxicity is similar. An animal proven to have aluminum toxicity from an ingested foreign body had symptoms of muscle twitching and convulsions during exercise, which worsened to weakened limbs and coma until the source of the toxicity was removed. PMID: 23609067 Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
Aluminum Ab.IgE:PrThr:Pt:Ser:SemiQn:RAST
Long Common Name
Aluminum IgE Ab [Presence] in Serum by Radioallergosorbent test (RAST)
Short Name
Aluminum IgE RAST
Display Name
Aluminum IgE RAST (S) [Presence]
Consumer Name Alpha Get Info
Aluminum allergy test

Part Model Get Info

Basic Attributes

Class
ALLERGY
Type
Laboratory
First Released
Version 2.78
Last Updated
Version 2.79 (NAM)
Change Reason
Release 2.79: COMPONENT: added antibody nomenclature;
Order vs. Observation
Observation

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Hliník:Přítomnost nebo práh:Časový bod:Sérum:Semikvantitativní:Radioallergosorbent test (RAST)
el-GRGreek (Greece)Αλουμίνιο Ab.IgE:PrThr:Pt:Ορός:Ημιποσοτική:RAST
Synonyms: Ab.IgE ALLERGY PrThr Pt RAST Αλουμίνιο Ανοσοσφαιρίνη E Αντίσωμα Ημιποσοτική Ορός
es-ESSpanish (Spain)Aluminio IgE:PrThr:Punto temporal:Suero:Semicuantitativo:Prueba de absorcion de radioalergeno (RAST)
Synonyms: Semicuantitativo
fr-FRFrench (France)Aluminium Ac IgE:Présence/Seuil:Ponctuel:Sérum:Semi-Quantitatif:RAST
fr-CAFrench (Canada)Aluminium, IgE:Présence-Seuil:Temps ponctuel:Sérum:SemiQn:RAST
it-ITItalian (Italy)Alluminio Ab.IgE:PrThr:Pt:Siero:SemiQn:RAST
Synonyms: anticorpi anti-IgE anticorpo Presenza o Soglia Punto nel tempo (episodio) Risposta agli antigeni Siero Test di radioallergoassorbimento (RAST)
nl-NLDutch (Netherlands)aluminium As.IgE:aanwezigheid:moment:serum:semikwantitatief:RAST
Synonyms: antistof; antilichaam radioallergosorbent test
zh-CNChinese (China)铝 抗体.IgE:存在情况或阈值:时间点:血清:半定量型:放射过敏原吸附试验法
Synonyms: Ab.IgE;IgE;抗体 IgE Ab;自身抗体 AL 免疫球蛋白 E 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 放射过敏原吸附试验;放射过敏原吸附试验（Radioallergosorbent Test，RAST） 时刻;随机;随意;瞬间

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=104842-0