LOINC
Version 2.68

10498-4Keratin Ag [Presence] in Tissue by Immune stainActive

Part Descriptions

LP14679-2   Keratin
A class of fibrous proteins or scleroproteins important both as structural proteins and as keys to the study of protein conformation. The family represents the principal constituent of epidermis, hair, nails, horny tissues, and the organic matrix of tooth enamel. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms an alpha-helix, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. Source: National Library of Medicine, MeSH 2006

LP14679-2   Keratin
Keratin refers to a family of fibrous structural proteins. Keratin is the key of structural material making up the outer layer of human skin. It is also the key structural component of hair and nails.

Some infectious fungi, such as those that cause athlete's foot and ringworm (i.e. the dermatophytes), or Batrachochytrium dendrobatidis (Chytrid fungus), feed on keratin.

Diseases caused by mutations in the keratin genes include Epidermolysis bullosa simplex, Ichthyosis bullosa of Siemens, Epidermolytic hyperkeratosis, Steatocystoma multiplex, Keratosis pharyngis, Rhabdoid cell formation in Large cell lung carcinoma with rhabdoid phenotype.

Furthermore, keratin expression is helpful in determining epithelial origin in anaplastic cancers. Tumors that express keratin include carcinomas, thymomas, sarcomas and trophoblastic neoplasms. Furthermore, the precise expression pattern of keratin subtypes allows prediction of the origin of the primary tumor when assessing metastases. For example, hepatocellular carcinomas typically expresse K8 and K18, and cholangiocarcinomas express K7, K8 and K18, while metastases of colorectal carcinomas express K20, but not K7 Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component
Keratin Ag
Property
PrThr
Time
Pt
System
Tiss
Scale
Ord
Method
Immune stain

Additional Names

Short Name
Keratin Ag Tiss Ql ImStn
Display Name
Keratin Ag Immune stain Ql (Tiss)

Basic Attributes

Class
PATH
Type
Laboratory
First Released
Version 1.0i
Last Updated
Version 2.56
Change Reason
The PrThr property is used for LOINC terms whose results are reported using an ordered categorical scale, regardless of whether or not an internal threshold was used to make that determination. This change was approved by the Laboratory LOINC Committee in June 2016.
Order vs. Observation
Both

Language Variants Get Info

zh-CNChinese (CHINA)
角蛋白 抗原:存在情况或阈值:时间点:组织与涂片:序数型:免疫染色法
nl-NLDutch (NETHERLANDS)
keratine Ag:aanwezigheid:moment:weefsel en uitstrijkjes:ordinaal:immunokleuring
et-EEEstonian (ESTONIA)
Keratiin antigeen:PrThr:Pt:Tis:Ord:Immuunvärv
fr-BEFrench (BELGIUM)
Kératine Ag:PrThr:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
fr-CAFrench (CANADA)
Kératine , Ag:Présence-Seuil:Temps ponctuel:Tissu:Ordinal:Coloration immunologique
fr-FRFrench (FRANCE)
Kératine antigène:Présence/Seuil:Ponctuel:Tissu:Qualitatif:Coloration immune
it-ITItalian (ITALY)
Cheratina , Ag:PrThr:Pt:Tessuto:Ord:Colorazione immunologica
ko-KRKorean (KOREA, REPUBLIC OF)
케라틴 항원:임의농도:검사시점:조직:순위척도:면역염색
pt-BRPortuguese (BRAZIL)
Queratina Ag:ACnc:Pt:Tecido:Ord:Imunocoloração
ru-RURussian (RUSSIAN FEDERATION)
Кератин Аг:PrThr:ТчкВрм:Тк:Пор:Иммуногистохимическая окраска
es-ARSpanish (ARGENTINA)
antígeno de queratina:concentración arbitraria:punto en el tiempo:tejido, no especificado:ordinal:tinción inmunológica
es-ESSpanish (SPAIN)
Queratina Antígeno:PrThr:Punto temporal:Tejido:Ord:Tinción de inmunohistoquímica
tr-TRTurkish (TURKEY)
Keratin Ag:MevcEşik:Zmlı:Doku:Srl:İmmün boyama

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=10498-4