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Part Descriptions

LP30823-6   Amyloid beta 42 peptide
Abeta 42 level is elevated in individuals whose chromosomes carry the genetic mutations characteristic of the early form of Alzheimer's. Source: Regenstrief Institute

LP30823-6   Amyloid beta 42 peptide
Amyloid beta (Aβ or Abeta) is a peptide of 36-43 amino acids that is processed from the Amyloid precursor protein. While it is most commonly known in association with Alzheimer's disease, it does not exist specifically to cause disease. Evidence has been found that Aβ has multiple non-disease activities.

The most common isoforms are Aβ40 and Aβ42; the shorter form is typically produced by cleavage that occurs in the endoplasmic reticulum, while the longer form is produced by cleavage in the trans-Golgi network. The Aβ40 form is the more common of the two, but Aβ42 is the more fibrillogenic and is thus associated with disease states. Mutations in APP associated with early-onset Alzheimer's have been noted to increase the relative production of Aβ42, and thus one suggested avenue of Alzheimer's therapy involves modulating the activity of β and γ secretases to produce mainly Aβ40.

Increases in either total Aβ levels or the relative concentration of both Aβ40 and Aβ42 (where the former is more concentrated in cerebrovascular plaques and the latter in neuritic plaques) have been implicated in the pathogenesis of both familial and sporadic Alzheimer's disease. Due to its more hydrophobic nature, the Aβ42 is the most amyloidogenic form of the peptide. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LOINC Names Get Info

Fully-Specified Name
Amyloid beta 42 peptide/Amyloid beta 40 peptide:MRto:Pt:Plas:Qn:LC/MS/MS
Long Common Name
Amyloid beta 42 peptide/Amyloid beta 40 peptide [Mass Ratio] in Plasma by LC/MS/MS
Short Name
Abeta42/ABeta40 Plas LC/MS/MS
Display Name
Amyloid beta 42 peptide/Amyloid beta 40 peptide LC/MS/MS (P) [Mass ratio]
Consumer Name Alpha Get Info
Amyloid beta 42 peptide/Amyloid beta 40 peptide, Blood

Part Model Get Info

  • Component
    Amyloid beta 42 peptide/Amyloid beta 40 peptide
    LP428139-2
    • Analyte
      Amyloid beta 42 peptide/Amyloid beta 40 peptide
      LP428139-2
      • Component Numerator
        Amyloid beta 42 peptide
        LP30823-6
        • Component Numerator Core
          Amyloid beta 42 peptide
          LP30823-6
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        Amyloid beta 40 peptide
        LP428154-1
        • Component Denominator Core
          Amyloid beta 40 peptide
          LP428154-1
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    MRto
    LP6834-8
  • Time
    Pt
    LP6960-1
  • System
    Plas
    LP7479-1
    • System Core
      Plas
      LP7479-1
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    LC/MS/MS
    LP95062-3

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.79
Last Updated
Version 2.79 (ADD)
Order vs. Observation
Observation

Formula (Readable)

Aβ42/40 Ratio - concentration of amyloid beta(Aβ)42 divided by Aβ40

Language Variants Get Info

TagLanguageTranslation
el-GRGreek (Greece)β-αμυλοειδές πεπτίδιο 42/β-αμυλοειδές πεπτίδιο 40:MRto:Pt:Πλάσμα:Qn:LC/MS/MS
Synonyms: CHEM LC/MS/MS MRto Pt Qn β-αμυλοειδές πεπτίδιο 40 β-αμυλοειδές πεπτίδιο 42 Πλάσμα
es-ESSpanish (Spain)Péptido beta amiloide 42/Péptido amiloide beta 40 (Aβ40):Relacion de Masa:Punto temporal:Plasma:Qn:LC/MS/MS
Synonyms: Cuantitativo
fr-FRFrench (France)Peptide bêta amyloïde 1-42/peptide bêta amyloïde 1-40:Masse ratio:Ponctuel:Plasma:Numérique:LC/MS/MS
it-ITItalian (Italy)Amiloide beta 42 peptide/Amiloide beta 40 peptide:MRto:Pt:Plasma:Qn:LC/MS/MS
Synonyms: Chimica Plasma Punto nel tempo (episodio) Rapporto di Massa
nl-NLDutch (Netherlands)amyloïd-bèta-42-peptide/amyloïd-bèta-40-peptide:massaverhouding:moment:plasma:kwantitatief:LC/MS/MS
Synonyms: amyloid beta 40 peptide amyloid beta 42 peptide
pl-PLPolish (Poland)Peptyd amyloidu beta 42/amyloid beta 40 peptyd:współczynnik masowy:punkt w czasie:osocze:ilościowy:chromatografia cieczowa z tandemową spektrometrią mas (LC-MS/MS)
Synonyms: amyloid beta 40;amyloid-beta-40 Peptyd amyloidu beta 40
zh-CNChinese (China)淀粉样蛋白 Beta 42 肽/淀粉样蛋白 Beta 40 肽:质量比率:时间点:血浆:定量型:LC/MS/MS
Synonyms: Ab40 肽;淀粉状蛋白 Beta 40 肽 Ab42 peptide;Ab42 肽;Abeta 42;AL beta42;Alzheimer 氏病;Alzheimer 病;Alzheimer氏病;Alzheimer病;Beta 淀粉样肽;Beta-淀粉样肽;Beta-淀粉样蛋白;Beta-淀粉状朊;Beta-淀粉状蛋白;β淀粉样肽;β-淀粉样肽;β-淀粉样蛋白;β-淀粉状朊;β-淀粉状蛋白;淀粉状蛋白 Beta 42 肽;淀粉样蛋白β42 肽;淀粉状朊 Beta 42 肽;淀粉状朊β42 肽;淀粉状蛋白β42 肽;老年性痴呆;老年痴呆;阿尔茨海默病 B Tandem Mass Spectrometry;MS/MS;串联质谱分析;串联质谱法;mass spectrometer;MS;质谱法;质谱分析;liquid chromatography;LC;液相色谱分析;Liquid Chromatography-Tandem Mass Spectrometry;liquid chromatography-MS/MS;LC-MS/MS;液相色谱分析-串联质谱分析法;液相色谱-串联质谱检测方法;液相色谱质谱联用技术;串联质谱快速分析 β β淀粉样蛋白;淀粉样β蛋白 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 来自于同一体系的两种分析物的质量之比;质量比 淀粉样蛋白 淀粉状朊 淀粉状蛋白 Beta 40 肽;Ab40 peptide;Ab40 肽;Abeta 40;AL beta40;Alzheimer 氏病;Alzheimer 病;Alzheimer氏病;Alzheimer病;Beta 淀粉样肽;Beta-淀粉样肽;Beta-淀粉样蛋白;Beta-淀粉状朊;Beta-淀粉状蛋白;β淀粉样肽;β-淀粉样肽;β-淀粉样蛋白;β-淀粉状朊;β-淀粉状蛋白;淀粉样蛋白β40 肽;淀粉状朊 Beta 40 肽;淀粉状朊β40 肽;淀粉状蛋白β40 肽;老年性痴呆;老年痴呆;阿尔茨海默病 硫酸胶化纤维素 类淀粉物 缩氨酸 胶化纤维素 贝塔

Example Units

UnitSource
{ratio}Example UCUM Units

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=106941-8